Results 221 to 230 of about 105,918 (288)

Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies

Nature Communications, 2022
Programmable double-strand DNA breaks (DSBs) can be harnessed for precision genome editing through manipulation of the homology-directed repair (HDR) pathway.
Zsolt Bodai, Alena L Bishop, Valentino Matteo Gantz   +2 more
exaly   +2 more sources

A universal SNP and small-indel variant caller using deep neural networks

Nature Biotechnology, 2018
Ryan Poplin, Pi-Chuan Chang, Lizzie Dorfman   +2 more
exaly   +2 more sources

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Correcting a Single Indel/Edit for DNA-Based Data Storage: Linear-Time Encoders and Order-Optimality

IEEE Transactions on Information Theory, 2021
An indel refers to a single insertion or deletion, while an edit refers to a single insertion, deletion or substitution. In this article, we investigate codes that correct either a single indel or a single edit and provide linear-time algorithms that ...
K. Cai, Y. Chee, Ryan Gabrys, Han Mao Kiah, T. T. Nguyen   +4 more
semanticscholar   +1 more source

Development and validation of a forensic multiplex InDel assay: The AGCU InDel 60 kit

Electrophoresis, 2022
Marker sets based on insertion/deletion polymorphisms (InDels) combine the characteristics of both short tandem repeats (STRs) and single nucleotide polymorphisms and have served as effective complementary or stand‐alone systems for human identification ...
Jing Liu, Weian Du, Lirong Jiang, Changhui Liu, Ling Chen, Yangyang Zheng, Yiping Hou, Chao Liu, Zheng Wang   +8 more
semanticscholar   +1 more source

Indel-K2P: a modified Kimura 2 Parameters (K2P) model to incorporate insertion and deletion (Indel) information in phylogenetic analysis

Cyber-Physical Systems, 2021
Evolutionary models are widely used to estimate the evolutionary relationship between the various biological taxa . Majority of the existing evolutionary models ignore insertion and deletion (indel) event, which reduces the computational difficulties ...
Asim Kumar Mahadani, Shashank Awasthi, G. Sanyal, P. Bhattacharjee, S. Pippal   +4 more
semanticscholar   +1 more source

A multiallelic indel in the promoter region of the Cyclin-dependent kinase inhibitor 3 gene is significantly associated with body weight and carcass traits in chickens

Poultry Science, 2019
Many studies have reported that cyclin‐dependent kinase inhibitor 3 (CDKN3) is involved in the cell cycle. However, the function of CDKN3 has not been well elucidated in organisms.
Wenya Li, Ruili Han, Guoxi Li
exaly   +2 more sources

Indel mutations of sheep PLAG1 gene and their associations with growth traits

Animal Biotechnology, 2021
Pleiomorphic adenoma gene 1 (PLAG1) is mainly expressed in embryonic development, and it is reported to take an effect on the growth performance of mice, cattle, pigs, and sheep.
Yun Pan, Min Wang, Hui Wu, Zhanerke Akhatayeva, X. Lan, Panfeng Fei, Cui Mao, Fugui Jiang   +7 more
semanticscholar   +1 more source

Improved indel detection in DNA and RNA via realignment with ABRA2

Bioinformatics, 2019
Motivation Genomic variant detection from next-generation sequencing has become established as an extremely important component of research and clinical diagnoses in both cancer and Mendelian disorders.
Charles M Perou, Joel S Parker
exaly   +2 more sources

The InDel variants of sheep IGF2BP1 gene are associated with growth traits

Animal Biotechnology, 2021
Insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) plays positive roles in the growth, proliferation of cells and early embryos development by binding mRNA targets.
Hongfei Liu, Hongwei Xu, Xianyong Lan, Xiu-Kai Cao, C. Pan   +4 more
semanticscholar   +1 more source