Results 41 to 50 of about 105,918 (288)
SInC: An accurate and fast error-model based simulator for SNPs, Indels and CNVs coupled with a read generator for short-read sequence data [PDF]
, 2013 We report SInC (SNV, Indel and CNV) simulator and read generator, an open-source tool capable of simulating biological variants taking into account a platform-specific error model. SInC is capable of simulating and generating single- and paired-end reads
Gupta, Saurabh +3 more
core +2 more sources
Unconventional conservation reveals structure-function relationships in the synaptonemal complex
eLife, 2021 Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged ...
Lisa E Kursel, Henry D Cope, Ofer Rog
doaj +1 more source
A universal method for automated gene mapping [PDF]
, 2005 Small insertions or deletions (InDels) constitute a ubiquituous class of sequence polymorphisms found in eukaryotic genomes. Here, we present an automated high-throughput genotyping method that relies on the detection of fragment-length polymorphisms ...
Basler, Konrad +6 more
core +2 more sources
Nucleic Acids Research, 2020 Advances in genome editing technologies have enabled manipulation of genomes at the single base level. These technologies are based on programmable nucleases (PNs) that include meganucleases, zinc-finger nucleases (ZFNs), transcription activator-like ...
E. Bennett +8 more
semanticscholar +1 more source
한국균학회지, 2021 Lentinula edodes (Berk.) Pegler, the most produced mushroom in the world, is an edible mushroom with very high nutritional and pharmacological value. Currently, interest in the protection of genetic resources is increasing worldwide, and securing the ...
Suyun Moon +3 more
doaj +1 more source
Molecular recording of mammalian embryogenesis. [PDF]
, 2019 Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt +13 more
core +2 more sources
Development and Optimization of CRISPR Prime Editing System in Photoautotrophic Cells
Molecules, 2022 Prime editor (PE), a versatile editor that allows the insertion and deletion of arbitrary sequences, and all 12-point mutations without double-strand breaks (DSB) and a donor template, dramatically enhances research capabilities. PE combines nickase Cas9(
Zhengzheng Jiang +5 more
doaj +1 more source
Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel loci [PDF]
Royal Society Open Science, 2020 According to historical records, ethnic Hui in China obtained substantial genetic components from western Eurasian populations during their Islamization. However, some scholars believed that the ancestry of Hui people were native Chinese populations.
Boyan Zhou +4 more
doaj +1 more source
Animals, 2020 Simple Summary As a major gene to regulate the muscle mass of animals, Myostatin (MSTN) plays a negative role in regulating the number and size of skeletal myocytes.
Yi Bi +7 more
semanticscholar +1 more source
Comparative chloroplast genomics of the genus Taxodium
BMC Genomics, 2020 Background Chloroplast (cp) genome information would facilitate the development and utilization of Taxodium resources. However, cp genome characteristics of Taxodium were poorly understood.
Hao Duan +6 more
doaj +1 more source