Results 11 to 20 of about 54,945 (293)

Genetic Drift and Indel Mutation in the Evolution of Yeast Mitochondrial Genome Size. [PDF]

Genome Biol Evol, 2017
Mitochondrial genomes (mitogenomes) are remarkably diverse in genome size and organization, but the origins of dynamic mitogenome architectures are still poorly understood. For instance, the mutational burden hypothesis postulates that the drastic difference between large plant mitogenomes and streamlined animal mitogenomes can be driven by their ...
Xiao S, Nguyen DT, Wu B, Hao W.
europepmc   +4 more sources

Evolution of a Record-Setting AT-Rich Genome: Indel Mutation, Recombination, and Substitution Bias. [PDF]

Genome Biol Evol, 2020
AbstractGenome-wide nucleotide composition varies widely among species. Despite extensive research, the source of genome-wide nucleotide composition diversity remains elusive. Yeast mitochondrial genomes (mitogenomes) are highly A + T rich, and they provide a unique opportunity to study the evolution of AT-biased landscape.
Nguyen DT, Wu B, Xiao S, Hao W.
europepmc   +4 more sources

IndelsRNAmute: predicting deleterious multiple point substitutions and indels mutations

BMC Bioinformatics, 2022
Abstract Background RNA deleterious point mutation prediction was previously addressed with programs such as and . The purpose of these programs is to predict a global conformational rearrangement of the secondary structure of a functional RNA molecule, thereby disrupting its function.
Alexander Churkin, Yann Ponty, Danny Barash   +2 more
openaire   +4 more sources

Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs [PDF]

Neuro-Oncology, 2023
Abstract Background Schwannomas are common peripheral nerve sheath tumors that can cause severe morbidity given their stereotypic intracranial and paraspinal locations. Similar to many solid tumors, schwannomas and other nerve sheath tumors are primarily thought to arise due to aberrant ...
Erik A Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O Stevers, Abigail K Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G Lucas, Emily Chan, Melike Pekmezci, Philip E LeBoit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W Patrick Devine, Alyssa T Reddy, Nalin Gupta, Kristen M Basnet, Robert J B Macaulay, Patrick Malafronte, Han Lee, William H Yong, Kevin Jon Williams, Tareq A Juratli, Douglas A Mata, Richard S P Huang, Matthew C Hiemenz, Dean C Pavlick, Garrett M Frampton, Tyler Janovitz, Jeffrey S Ross, Susan M Chang, Mitchel S Berger, Line Jacques, Jun S Song, Joseph F Costello, David A Solomon   +40 more
openaire   +3 more sources

Digital-Droplet PCR to Detect Indels Mutations in Genetically Modified Anopheline Mosquito Populations [PDF]

Journal of Visualized Experiments, 2021
Recent advances in mosquito genomics and genetic engineering technologies have fostered a need for quick and efficient methods for detecting targeted DNA sequence variation on a large scale. Specifically, detecting insertions and deletions (indels) at gene-edited sites generated by CRISPR guide RNA (gRNA)/Cas9-mediated non-homologous end-joining (NHEJ)
Carballar-Lejarazú, Rebeca, Pham, Thai Binh, Kelsey, Adam, Tushar, Taylor, James, Anthony A   +4 more
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Asymmetric somatic hybridization induces point mutations and indels in wheat [PDF]

BMC Genomics, 2015
Allopolyploid genome needs wide structural variation to deal with genomic shock. The introgression line, generated via asymmetric somatic hybridization, is introgressed with a minimum of exogenous chromatin, which also leads to genomic shock to induce genetic variation.
Wang, Mengcheng, Liu, Chun, Xing, Tian, Wang, Yanxia, Xia, Guangmin   +4 more
openaire   +2 more sources

DeNovoGear: de novo indel and point mutation discovery and phasing [PDF]

Nature Methods, 2013
We present DeNovoGear software for analyzing de novo mutations from familial and somatic tissue sequencing data. DeNovoGear uses likelihood-based error modeling to reduce the false positive rate of mutation discovery in exome analysis and fragment information to identify the parental origin of germ-line mutations.
Avinash, Ramu, Michiel J, Noordam, Rachel S, Schwartz, Arthur, Wuster, Matthew E, Hurles, Reed A, Cartwright, Donald F, Conrad   +6 more
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The pioneering role of PRDM9 indel mutations in tarsier evolution [PDF]

Scientific Reports, 2016
Abstract PRDM9 is currently the sole speciation gene found in vertebrates causing hybrid sterility probably due to incompatible alleles. Its role in defining the double strand break loci during the meiotic prophase I is crucial for proper chromosome segregation. Therefore, the rapid turnover of
Heerschop, Sacha, Zischler, Hans, Merker, Stefan, Perwitasari-Farajallah, Dyah, Driller, Christine   +4 more
openaire   +4 more sources

Indel-Associated Mutation Rate Varies with Mating System in Flowering Plants [PDF]

Molecular Biology and Evolution, 2009
A recently proposed mutational mechanism, indel-associated mutation (IDAM), posits that heterozygous insertions/deletions (indels) increase the point mutation rate at nearby nucleotides due to errors during meiosis. This mechanism could have especially dynamic consequences for the evolution of plant genomes, because the high degree of variation in the ...
Jesse D, Hollister, Jeffrey, Ross-Ibarra, Brandon S, Gaut   +2 more
openaire   +2 more sources

The ovine HIAT1 gene: mRNA expression, InDel mutations, and growth trait associations

Frontiers in Veterinary Science, 2023
BackgroundThe hippocampal abundant transcript 1 (HIAT1) gene, also known as major facilitator superfamily domain-containing 14A (MFSD14A), encodes for a transmembrane transporter protein and has been previously shown to be associated with milk production in buffalo and sheep breeds, as well as growth traits in chicken and goats.
Yunyun Luo, Zhanerke Akhatayeva, Cui Mao, Cui Mao, Fugui Jiang, Zhengang Guo, Hongwei Xu, Xianyong Lan   +7 more
openaire   +3 more sources