Results 191 to 200 of about 54,945 (293)
Comprehensive analysis reveals the molecular heterogeneity and the differences in prognosis and immunotherapy sensitivity in hypermutated colorectal cancer. [PDF]
Medicine (Baltimore)Bai G, Yang X, Xiao L, Xiong C.
europepmc +1 more source
Neoclassical development of genetic sexing strains for insect pest and disease vector control
Insect Science, EarlyView.The sterile insect technique has been effectively used for decades, and an important component is the availability of sex separation systems, in particular genetic sexing strains. Classical approaches, such as irradiation‐induced chromosomal translocations, have yielded stable strains for species like the Mediterranean fruit fly.
Giovanni Petrucci +5 more
wiley +1 more source
Cryptorchidism: Novel genetic insights into CCDC149 mutations
Andrology, EarlyView.Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du +8 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary T‐follicular helper cell lymphomas (TFHLs) are frequently associated with epigenetic mutations and clonal haematopoiesis (CH), but the clinical and prognostic implications of CH in TFHL remains unclear. We performed next‐generation sequencing on paired peripheral blood (PB) and tumour tissue samples from 30 patients with TFHL. CH was defined by
Chong Wei +4 more
wiley +1 more source
Microhomology-mediated end joining is the predominant form of DNA repair in the mosquito Aedes aegypti with implications for gene editing, gene drive, and transgene removal. [PDF]
Nucleic Acids ResRomanowski JS, Myles KM, Adelman ZN.
europepmc +1 more source
A century of theories of balancing selection
Biological Reviews, EarlyView.ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka +10 more
wiley +1 more source
ARROW: Allele-Specific Recombined gRNA Design for Reduced Off-Target with Enhanced Specificity. [PDF]
Bioengineering (Basel)Bae T +5 more
europepmc +1 more source
Cancer Science, EarlyView.Our findings indicate that a pediatric/AYA‐specific targeted panel deployed in a hospital can deliver rapid, clinically actionable molecular insights with high diagnostic and prognostic yield. This complements larger sequencing platforms by offering speed, focused content, and easier interpretation.
Masato Kojima +8 more
wiley +1 more source
Mapping the Prevalence of Lynch Syndrome in the Ceará—Northeast of Brazil
Clinical Genetics, EarlyView.Distribution of pathogenic variants associated with Lynch syndrome across Brazil, with a particular emphasis on the state of Ceará. The illustration highlights the most frequently reported MMR genetic variants in Brazil and provides a magnified view of Ceará, where three novel variants were identified in the APC, SMAD4, and MSH6 genes within specific ...
Maria Claudia dos Santos Luciano +8 more
wiley +1 more source