Domestication‐Selected Promoter Insertion in WRKY17 Increases Cadmium Sensitivity in Apple
ABSTRACT With increasing industrialisation and human activities, heavy metal pollution has become a serious environmental concern, particularly cadmium (Cd) contamination. This study reveals significant differences in Cd tolerance between wild apple (Malus spp.) and cultivated apple (Malus domestica).
Chanyu Wang +15 more
wiley +1 more source
Tumor mutational burden predicts neoantigen profiles and immunotherapy response in microsatellite stable tumors across different cancer types. [PDF]
Kondrateva O +3 more
europepmc +1 more source
Natural Variation of a PPR Coding Gene SST1 Confers Salt Tolerance During Soybean Domestication
ABSTRACT Soil salinity is one of the constraints that adversely affect seedling growth and limit soybean yield. Identifying salt tolerance genes and profiling their allele variants are crucial for elucidating the mechanisms underlying salt tolerance in soybean and enabling the genetic improvement of salt‐tolerant cultivars.
Hui Wang +14 more
wiley +1 more source
Engineered AcrIIA5 for optogenetic control of CRISPR-Cas9-based genome editing. [PDF]
Chen Q +5 more
europepmc +1 more source
Fine mapping of the major-effect QTL <i>qPHS4.1</i> revealed a <i>CsDOG1</i> gene controlling pre-harvest sprouting in cucumber (<i>Cucumis sativus</i> L.). [PDF]
Cao M +5 more
europepmc +1 more source
ABSTRACT Cuticular waxes can form a hydrophobic barrier on aerial plant surfaces, which is essential for mediating plant‐environment interactions by providing protection against both biotic and abiotic stresses. In this study, a cuticular wax mutant (gl) was identified and characterised in Welsh onion (Allium fistulosum L.), exhibiting a functional ...
Jiayi Xing +5 more
wiley +1 more source
Single-cell analysis of the somatic mutational landscape in human chondrocytes during aging and in osteoarthritis. [PDF]
Ren P +16 more
europepmc +1 more source
A multimodal framework for comprehensive driver variant prediction in cancer. [PDF]
Yang H +9 more
europepmc +1 more source
ABSTRACT Heat stress (HS) has become an increasing threat to wheat productivity under global warming. However, the genetic loci for thermotolerance and the underlying molecular mechanisms remain largely unknown. In this study, genetic mapping identified a thermotolerance locus, QMpe.cau‐2D, encoding fatty acid desaturase 8 (FAD8), with the transposable
Hongjian Yu +15 more
wiley +1 more source
OmniNeo: a multi-omics pipeline incorporating proteomics and AI selection for neoantigen optimization in tumor immunotherapy. [PDF]
Lu M +11 more
europepmc +1 more source

