Results 21 to 30 of about 54,945 (293)
Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
Proceedings of the National Academy of Sciences, 2022 Significance The targeted killing of cancer cells without affecting surrounding normal cells is the most desirable approach for cancer therapy; however, it cannot be easily achieved, owing to the shared properties of normal and cancer cells.
Taejoon Kwon +25 more
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Heliyon, 2020 Background: Reversion mutations of somatic BRCA mutations are an important source of resistance within ovarian cancer. Furthermore, these reversion mutations are known to change over the course of treatment. Better understanding of the mechanisms leading
Saya L. Jacob +2 more
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Important role of indels in somatic mutations of human cancer genes [PDF]
BMC Medical Genetics, 2010 Abstract Background Cancer is clonal proliferation that arises owing to mutations in a subset of genes that confer growth advantage. More and more cancer related genes are found to have accumulated somatic mutations. However, little has been reported about mutational patterns of insertions/deletions (indels) in these ...
Yang Haiwang +4 more
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A method to build extended sequence context models of point mutations and indels [PDF]
Nature Communications, 2021 AbstractThe mutation rate of a specific position in the human genome depends on the sequence context surrounding it. Modeling the mutation rate by estimating a rate for each possible k-mer, however, only works for small values of k since the data becomes too sparse for larger values of k.
Jörn Bethune +2 more
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Animals, 2021 The A-kinase anchoring protein 12 gene (AKAP12) is a scaffold protein, which can target multiple signal transduction effectors, can promote mitosis and cytokinesis and plays an important role in the regulation of growth and development.
Yangyang Bai +7 more
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BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]
, 2016 Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien +7 more
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Fast neutron mutagenesis in soybean enriches for small indels and creates frameshift mutations [PDF]
G3 Genes|Genomes|Genetics, 2021 Abstract The mutagenic effects of ionizing radiation have been used for decades to create novel variants in experimental populations. Fast neutron (FN) bombardment as a mutagen has been especially widespread in plants, with extensive reports describing the induction of large structural variants, i.e., deletions, insertions, inversions ...
Skylar R Wyant +6 more
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BMC Genetics, 2020 Background G-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide. Chicken GNB1L is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that in low feed efficiency chickens ...
Tuanhui Ren +9 more
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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research [PDF]
, 2016 Accurate variant calling in next generation sequencing (NGS) is critical to understand cancer genomes better. Here we present VarDict, a novel and versatile variant caller for both DNA- and RNA-sequencing data.
Ahdesmaki, Miika +9 more
core +2 more sources
Media Peternakan, 2016 Genetic marker linked to loci reproductive traits could be used to increase an effectiveness of improvement in animal breeding. Association between DNA polymorphism and a trait could be considered as candidate genetic marker for marker assisted selection
M. Indriati, C. Sumantri, T. Susanti
doaj +1 more source