Results 31 to 40 of about 54,945 (293)
Genetic typing of isolates of Rickettsia typhi.
PLoS Neglected Tropical Diseases, 2022 Murine typhus, which is caused by Rickettsia typhi, has a wide range of clinical manifestations. It has a low mortality rate but may result in meningoencephalitis and interstitial pneumonia in severe cases.
Cecilia Y Kato +4 more
doaj +1 more source
Dynamics of transcription factor binding site evolution [PDF]
, 2015 Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key regulatory ...
Barton, Nicholas H. +3 more
core +6 more sources
A universal method for automated gene mapping [PDF]
, 2005 Small insertions or deletions (InDels) constitute a ubiquituous class of sequence polymorphisms found in eukaryotic genomes. Here, we present an automated high-throughput genotyping method that relies on the detection of fragment-length polymorphisms ...
Basler, Konrad +6 more
core +2 more sources
Scientific Reports, 2021 Targeted mutagenesis by programmable site-specific nucleases like CRISPR typically produce 1-base pair (bp) insertion or deletion (indel) mutations. Although several methods have been developed to detect such 1-bp indels, each method has pros and cons in
Hiroyuki Kakui +2 more
doaj +1 more source
Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. [PDF]
, 2017 Precise genetic modifications in model animals are essential for biomedical research. Here, we report a programmable "base editing" system to induce precise base conversion with high efficiency in zebrafish. Using cytidine deaminase fused to Cas9 nickase,
Bai, Haipeng +7 more
core +1 more source
Fine-Scale Signatures of Molecular Evolution Reconcile Models of Indel-Associated Mutation [PDF]
Genome Biology and Evolution, 2013 Genomic structural alterations that vary within species, known as large copy number variants, represent an unanticipated and abundant source of genetic diversity that associates with variation in gene expression and susceptibility to disease. Even short insertions and deletions (indels) can exert important effects on genomes by locally increasing the ...
Jovelin, Richard, Cutter, Asher D.
openaire +2 more sources
Frontiers in Genetics, 2022 Multiple mutational events of insertion/deletion occurring at or around InDel sites could form multi-allelic InDels and multi-InDels (abbreviated as MM-InDels), while InDels with random DNA sequences could imply a unique mutation event at these loci.
Yining Yao +7 more
doaj +1 more source
Organellar inheritance in the green lineage: insights from Ostreococcus tauri [PDF]
, 2013 Along the green lineage (Chlorophyta and Streptophyta), mitochondria and chloroplast are mainly uniparentally transmitted and their evolution is thus clonal. The mode of organellar inheritance in their ancestor is less certain.
Adam Eyre-Walker +56 more
core +1 more source
Equivalent indels--ambiguous functional classes and redundancy in databases. [PDF]
PLoS ONE, 2013 There is considerable interest in studying sequenced variations. However, while the positions of substitutions are uniquely identifiable by sequence alignment, the location of insertions and deletions still poses problems.
Jens Assmus +3 more
doaj +1 more source
Frontiers in Physiology, 2022 The birth weight of chickens does not significantly affect the weight at slaughter, while the different growth rate after birth was one of the important reasons for the difference in slaughter weight.
Shudai Lin +5 more
doaj +1 more source