Results 81 to 90 of about 54,945 (293)

A putative gene sbe3-rs for resistant starch mutated from SBE3 for starch branching enzyme in rice (Oryza sativa L.). [PDF]

PLoS ONE, 2012
Foods high in resistant starch (RS) are beneficial to prevent various diseases including diabetes, colon cancers, diarrhea and chronic renal or hepatic diseases.
Ruifang Yang, Chunlong Sun, Jianjiang Bai, Zhixiang Luo, Biao Shi, Jianming Zhang, Wengui Yan, Zhongze Piao   +7 more
doaj   +1 more source

Sequence-Based Mapping and Genome Editing Reveal Mutations in Stickleback Hps5 Cause Oculocutaneous Albinism and the casper Phenotype. [PDF]

, 2017
Here, we present and characterize the spontaneous X-linked recessive mutation casper, which causes oculocutaneous albinism in threespine sticklebacks (Gasterosteus aculeatus).
Hart, James C, Miller, Craig T
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Progressive Mauve: Multiple alignment of genomes with gene flux and rearrangement [PDF]

, 2009
Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.
Darling, Aaron E., Mau, Bob, Perna, Nicole T.   +2 more
core  

Evolutionary Inference via the Poisson Indel Process

, 2013
We address the problem of the joint statistical inference of phylogenetic trees and multiple sequence alignments from unaligned molecular sequences. This problem is generally formulated in terms of string-valued evolutionary processes along the branches ...
Alexandre Bouchard-Côté, Buiculescu, Cox, Dreyer, Hein, Hein, Huelsenbeck, Michael I. Jordan, Miklós, Nelesen, Roshan, Saitou, Searls, Wheeler   +13 more
core   +1 more source

In-Frame Indel Mutations in the Genome of the Blind Mexican Cavefish, Astyanax mexicanus [PDF]

Genome Biology and Evolution, 2019
AbstractOrganisms living in the subterranean biome evolve extreme characteristics including vision loss and sensory expansion. Despite prior work linking certain genes to Mendelian traits, the genetic basis for complex cave-associated traits remains unknown.
Daniel Berning, Hannah Adams, Heidi Luc, Joshua B Gross   +3 more
openaire   +2 more sources

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse

Molecular Therapy: Nucleic Acids, 2018
CRISPR/Cas9 has been confirmed as a distinctly efficient, simple-to-configure, highly specific genome-editing tool that has been used to treat monogenetic disorders.
Xiao-Rui Luan, Xiao-Ling Chen, Yue-Xiao Tang, Jin-Yan Zhang, Xiang Gao, Hai-Ping Ke, Zhao-Yu Lin, Xian-Ning Zhang   +7 more
doaj   +1 more source

Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk [PDF]

, 2008
Previously, a candidate gene linkage approach on brother pairs affected with prostate cancer identified a locus of prostate cancer susceptibility at D3S1234 within the fragile histidine triad gene (FHIT), a tumor suppressor that induces apoptosis ...
A Auton, A Esquela-Kerscher, A Fischer, A Latil, A Vecchione, Al B. Benson, AM Adams, AM Levin, Cathryn Lundberg, CC Spencer, Ching Ouyang, D Charlesworth, D Gordon, DA Nickerson, David Johnson, DJ Schaid, E Dudbridge, EM Reis, ET Dermitzakis, F Tajima, FM De La Vega, G Sozzi, G Thomas, Garrett Larson, GP Larson, Guillermo Rivas, HH Nelson, J Gudmundsson, J Gudmundsson, J Gudmundsson, James A. Stewart, JC Barrett, JC Fay, Jeffrey Weitzel, Jerry Slater, JM Bland, John Archambeau, John M. Kirkwood, JS Pedersen, JS Rhim, K Huebner, K Preacher, Louis Geller, M Bamshad, M Nei, M Stephens, M Stephens, M Yeager, Magnus Nordborg, Mary B. Daly, Matthew W. Hahn, N Yu, NA Becker, P Kapranov, Peter J. O'Dwyer, PI Lin, RA Eeles, Rebecca Sutphen, RL Fouts, RR Hudson, S Wooding, SB Gabriel, T Bersaglieri, Theodore G. Krontiris, V Chizhikov, Yan Ding, YX Fu, Z Guo   +67 more
core   +4 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source