Results 151 to 160 of about 3,091,998 (362)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Dormant Independence

, 2008
The construction of causal graphs from non-experimental data rests on a set of constraints that the graph structure imposes on all probability distributions compatible with the graph. These constraints are of two types: conditional independencies and algebraic constraints, first noted by Verma.
Shpitser, Ilya, Pearl, Judea
openaire   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Limited open repair for achilles tendon rupture in the setting of co-morbidities: A case series and technique review

Foot & Ankle Surgery: Techniques, Reports & Cases
An acute Achilles tendon rupture poses a difficult treatment strategy in both young and old patients. Commonly considered an injury of the middle aged “weekend warrior,” an Achilles tendon tear in a sedentary patient is quite debilitating.
James C. Connors, DPM, FACFAS, Mark A. Hardy, DPM, FACFAS, Halle L. Krebs, Ali A. Manji, DPM, Cory M. Jarosi, DPM   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Our Lives, Our Fortunes, and Our Sacred Honor: The Forging of American Independence, 1774–1776 by Richard R. Beeman (review) [PDF]

, 2016
Jim Blackburn
openalex  

Achieving media independence through legal and regulatory measures: A formality or reality?

, 2018
Jacob Nyarko, Eric Opoku Mensah, Stephen Kwame Owusu-Amoh   +2 more
openalex   +1 more source

The struggle for independence in Mozambique by Eduardo Mondlane, 1963 Apr. 11-13

, 2021
Unknown
openalex   +1 more source

The effect of nursing education strategies based on health promotion model on increasing family independence in caring for maternal health [PDF]

, 2022
Naharia Laubo, Ruslan Hasani, Iwan, Sri Wahyuni Awaluddin, Sukriyadi, Sitti Aminah, Nuraeni Jalil, Abdul Kadir Ahmad, Hasifah, Hamsina Hamsina   +9 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source