Results 201 to 210 of about 651,740 (292)

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao, Zhili Wang, Hyoyong Kim, Hui Kong, Junseok Lee, Jacqueline Ziqian Yang, Anmin Wang, Ryan Y. Zhang, Yong Ju, Jina Kim, Bing Feng, Dejun Liu, Yating Zhang, Zhenfang Wang, Yandong Zhang, Shujing Guo, Dekang Gao, James S. Tomlinson, Renjun Pei, Jipeng Wan, Stephen J. Pandol, Myung‐Shin Sim, Sungyong You, Ding Ma, Shaohua Lu, Na Sun, Hsian‐Rong Tseng, Yazhen Zhu   +27 more
wiley   +1 more source

Refining the Allostatic Self-Efficacy Theory of Fatigue and Depression Using Causal Inference. [PDF]

Entropy (Basel)
Hess AJ, von Werder D, Harrison OK, Heinzle J, Stephan KE.   +4 more
europepmc   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

A tutorial on pharmacometric Markov models. [PDF]

CPT Pharmacometrics Syst Pharmacol
Ooi QX, Plan E, Bergstrand M.
europepmc   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Inverse Design of Highly Deformable Mechanical Metamaterial Based on Partitional Semi‐Random Optimization

Advanced Science, EarlyView.
This research presents a novel optimization method for the inverse design of flexible mechanical metamaterials, enhancing traditional strategies by evaluating deformation in subregions. Combining simulated annealing with a genetic algorithm, it improves design efficiency and enables customizable deformation paths.
Xueqing Cao, Zeang Zhao, Panding Wang, Shengyu Duan, Hongshuai Lei   +4 more
wiley   +1 more source

Reliability of a probabilistic knowledge structure. [PDF]

Behav Res Methods
de Chiusole D, Granziol U, Spoto A, Stefanutti L.   +3 more
europepmc   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Risk and Protective Factors of Conflicts Between Hospitalized Older Adults and Their Family Members: Structural Equation Modeling (SEM). [PDF]

Behav Sci (Basel)
Shulyaev K, Zisberg A, Gur-Yaish N.
europepmc   +1 more source

Time‐Resolved Dynamics of Laser Ablation in Liquid with Gas‐Evolving Additives: Toward Molding the Atomic Structure of Nonequilibrium Nanoalloys

Advanced Science, EarlyView.
Laser ablation in liquid still holds great potential for the synthesis of multicomponent non‐equilibrium nanomaterials. Here, time‐resolved experiments reveal that gas‐evolving additives both have chemical effects and reduce shockwave pressure. This approach offers a strategy to control the atomic structure of the nanoalloys, easily switching from ...
Vito Coviello, Catherine Reffatto, Mehdi W. Fawaz, Benoit Mahler, Arnaud Sollier, Bratislav Lukic, Alexander Rack, David Amans, Vincenzo Amendola   +8 more
wiley   +1 more source