Results 221 to 230 of about 8,737,377 (294)

Insights into cytotoxic, metastasis-related effects and α-glucosidase inhibitory activities of the <i>n</i>-hexane extract and two isolated triterpenoids from <i>Gymnosporia chevalieri</i> leaves. [PDF]

RSC Adv
Doan NAT, Tran TH, Singharajkomron N, Pongrakhananon V, Loha C, Prachatimutte K, Nguyen HM, Hoang HNT, Pham TV, Nguyen HT, Nguyen LTK, Ho DV.   +11 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Leveraging Google location history data to assess the impact of activities, locations, and time spent in green space on mental health during the COVID-19 pandemic. [PDF]

Am J Epidemiol
Amiri S, Amram O, Oje F, Avery AR, Gebremedhin A, Duncan GE, Hystad P.   +6 more
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

External validation of an integrative model of functional impairment in early-stage behavioral variant frontotemporal dementia (bvFTD). [PDF]

J Neurol
Chatzidimitriou E, Moraitou D, Ioannidis P, Aretouli E, Chen Y, Rosen HJ, Gorno-Tempini ML, Seeley WW, Miller BL, Rankin KP.   +9 more
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Developing a Dashboard to Stimulate Independent Functioning in Older Persons in District Nursing Care. [PDF]

Comput Inform Nurs
van den Braak KPM, Veldhuizen JD, Wulfse-Huisman S, Bakker J, Ruth E PL, Buurman BM, Zondervan-Zwijnenburg M, Zondervan-Zwijnenburg M, Bleijenberg N.   +8 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Higher preoperative Advanced Activities Score of the 2011 Knee Society Score is associated with greater patient satisfaction after ground kinematically aligned total knee arthroplasty. [PDF]

J Exp Orthop
Hayashi T, Matsumoto T, Ikuta K, Tsubosaka M, Kamenaga T, Kuroda Y, Nakano N, Ishida K, Hayashi S, Kuroda R.   +9 more
europepmc   +1 more source