Results 141 to 150 of about 8,737,377 (294)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteins [PDF]

J Gen Virol
Eke L, Tweedie A, Cutts S, Wise EL, Elliott G.   +4 more
europepmc   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A PROBLEMATIC APPROACH TO THE ORGANIZATION OF INDEPENDENT WORK AS A MEANS OF IMPROVING THE QUALITY OF KNOWLEDGE OF STUDENTS OF THE PEDAGOGICAL UNIVERSITY

Освітній вимір, 2010
The article deals with the problem concerning self-directed independent activities at a teacher training higher educational establishment on the basis of a task approach as the means of improvement student s knowledge quality.
M.A. Slyusarenko
doaj  

Yeast and Filaments Have Specialized, Independent Activities in a Zebrafish Model of Candida albicans Infection. [PDF]

Infect Immun, 2018
Seman BG, Moore JL, Scherer AK, Blair BA, Manandhar S, Jones JM, Wheeler RT.   +6 more
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities. [PDF]

Oncotarget, 2018
Ota S, Zhou ZQ, Hurlin PJ.
europepmc   +1 more source

State plan for independent living [PDF]

, 2002
The overall mission of the Arizona State Plan for Independent Living is to facilitate systemic enhancements and/or changes that promote and support the dignity, inclusion, independence, non-discrimination, and productivity of people with disabilities who

core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source