Results 221 to 230 of about 265,367 (299)

Maximal exercise at high altitude does not exacerbate inflammation in the human brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study investigated arterial–internal jugular venous (IJV) exchange of cytokines in response to low‐intensity and maximal cycling exercise at sea level and following 6–8 days at 3800 m a.s.l. There was a shift towards net release of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1 (MCP‐1) and ...
Hannah G. Caldwell   +11 more
wiley   +1 more source

Cortical responses to balance perturbations persist without active postural control

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A robotic balance simulator was used to test whether cortical responses to balance perturbations are contingent on active balance control or instead reflect the detection of unexpected motion. Participants experienced identical support‐surface rotations (toes‐up and toes‐down) while actively controlling balance or while being ...
Daphne N. R. Jansen   +3 more
wiley   +1 more source

P2X7 receptors promote atrial remodeling and atrial fibrillation susceptibility via reactive oxygen species‐mediated mitogen‐activated protein kinase signaling activation

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract Atrial fibrillation (AF), the most common clinical arrhythmia, is driven by inflammatory activation and oxidative stress, though precise molecular links remain unclear. This study identifies the P2X7 receptor as a key upstream regulator orchestrating proarrhythmic atrial remodeling through reactive oxygen species (ROS)‐mediated mitogen ...
Lingnan Zhang, Yeran Zhu, Xinshun Gu
wiley   +1 more source

Clot Composition Profiling in Large Vessel Occlusion Stroke Via Radiomics

open access: yesAnnals of Neurology, Volume 99, Issue 5, Page 1179-1188, May 2026.
Objective Clot composition may offer insights into the mechanism of ischemic stroke. Radiomics, a noninvasive imaging technique, enables tissue characterization through radiomic features (RFs). We aimed to evaluate clot composition using radiomics on non‐contrast computed tomography (NCCT).
Andres Gudino   +23 more
wiley   +1 more source

Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer's disease. [PDF]

open access: yesAlzheimers Res Ther
Li Q   +30 more
europepmc   +1 more source

HBO‐PC Reprograms Neuroimmune Metabolism Through Disruption of the LRG1‐HIF‐1α‐IL‐6‐STAT3 Amplification Loop Attenuates Pyroptosis and Ischemia–Reperfusion Injury

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
A mouse CIRI model was generated by middle cerebral artery occlusion. HBO‐PC and LRG1 siRNA knockdown were applied. Neurological function and molecular changes were evaluated. We confirmed that HBO‐PC reprograms neuroimmune metabolism through disruption of the LRG1‐HIF‐1α‐IL‐6‐STAT3 amplification Loop attenuates pyroptosis and ischemia–reperfusion ...
Wenying Lv   +5 more
wiley   +1 more source

Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision‐Making

open access: yesHuman Brain Mapping, Volume 47, Issue 7, May 2026.
Hippocampal theta power during memory retrieval predicts evidence accumulation in a mnemonic similarity task. Trial‐level MEG signals were integrated with a linear ballistic accumulator model, revealing that theta oscillations modulate decision dynamics, linking neural variability to memory‐based discrimination performance.
Pei L. Robins   +7 more
wiley   +1 more source

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