Results 221 to 230 of about 7,147,780 (265)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Gerontechnology Acceptance in Thai Older Adult Care Facilities-Sensor Network and Machine Learning Adoption: Mixed Methods Study. [PDF]

JMIR Form Res
Ongkasuwan M, Cheasakul U, Judkrue A, Sajampun P.   +3 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Parkinson's disease in the United Arab Emirates (UAE): Emirates Neurology Society consensus guidelines. [PDF]

Front Neurol
Mittal SO, Iantorno V, Hassan A, Krystkowiak P, Sarathchandran P, Ramberg CJ, Alolama M, Maiti T, Cirasanambati M, Alsafi MY, Al Rukn S.   +10 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Personal, cultural and socio-economic determinants of childbearing reluctance in small families: a field-based study from Iran. [PDF]

BMC Pregnancy Childbirth
Honarvar B, Bayati M, Alimondegari M, Sadati AK, Bidares M, Rafiee F, Pooreisa MJ, Maghami H, Jamali F, Bita F, Lankarani KB.   +10 more
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Global practices in adapting cognitive behavioral therapy for ethnoracial populations with substance use disorders: a scoping review of adaptation strategies, treatment outcomes, and geographic gaps. [PDF]

Int J Ment Health Syst
Onyegesi O, Kennedy PMW, Hamilton S, Ruglass LM, Conway FN.   +4 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Translation, cross-cultural adaptation and preliminary psychometric evaluation of the Victoria Respiratory Congestion Scale into Spanish. [PDF]

BMC Palliat Care
Canal-Sotelo J, Martin-Marco A, Bottaro-Parra D, Blasi-Martínez R, Nitola-Mendoza L, Oller-Bonache A, Camí C, Barallat-Gimeno E.   +7 more
europepmc   +1 more source