Results 241 to 250 of about 3,030,309 (307)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Telecare and telehealth for informal carers: a research in 12 Member States on their benefits and policy role for the success

International Journal of Integrated Care, 2013
Stephanie Carretero, Clara Centeno, James Stewart   +2 more
doaj  

The TalkMeHome service for people with early dementia

International Journal of Integrated Care, 2012
Marike Hettinga, Jan Nauta, Lammie van den Bosch, Cristian Hesselman, Jeffrey Brangert, Martine de Jong, Marcel Roest, Matti Groot   +7 more
doaj  

Some of the next articles are maybe not open access.

Related searches:

Independent Living Alternatives

Nursing Standard, 2010
Independent Living Alternatives (ILA) advocate the rights of people with disabilities. Run by the clients it serves, the organisation provides a comprehensive range of personal assistance services.
openaire   +2 more sources

Independent Living

Activities, Adaptation & Aging, 1996
Residency acceptance guidelines for independent living facilities develop around either current staff and resident attitudes of independence, and/or established legally documented guidelines. This paper attempts to assess "well" older adults' perceptions of independence by means of a questionnaire, and to clarify and define guidelines for physical and ...
openaire   +1 more source

Independent Living

This chapter explores the theoretical foundations essential for promoting independent living among individuals with disabilities, focusing on the social model of disability, the capability approach, and self-determination theory. It examines how these frameworks inform practical interventions, policy advocacy, and the integration of emerging ...
Manjari Sharma, Sharad Gupta
openaire   +1 more source