Results 41 to 50 of about 252 (176)

Independent Natural Extension for Infinite Spaces: Williams-Coherence to the Rescue

, 2017
We define the independent natural extension of two local models for the general case of infinite spaces, using both sets of desirable gambles and conditional lower previsions. In contrast to Miranda and Zaffalon (2015), we adopt Williams-coherence instead of Walley-coherence.
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Universal cosmological solutions in Lovelock gravity

European Physical Journal C: Particles and Fields
This paper explores the Friedmann field equations within the framework of Lovelock gravity, a natural extension of Einstein’s gravity, focusing on both flat and open universes.
A. V. Nikolaev
doaj   +1 more source

Lymphocytes with Cytotoxic Activity Induce Rapid Microtubule Axonal Destabilization Independently and before Signs of Neuronal Death

ASN Neuro, 2013
MS (multiple sclerosis) is the most prevalent autoimmune disease of the CNS (central nervous system) historically characterized as an inflammatory and demyelinating disease.
Nichole M. Miller, Leah P. Shriver, Vijaya L. Bodiga, Avijit Ray, Sreemanti Basu, Rajiv Ahuja, Arundhati Jana, Kalipada Pahan, Bonnie N. Dittel   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Socio-economic factors affecting agro-forestry technology adoption in Nyando, Kenya

Journal of Water and Land Development, 2018
Agro-forestry (AFR) technologies are perceived to improve livelihoods and natural resource sustainability of the rural households. Despite their aggressive promotion by multiple national and international agencies, the adoption of AFR technologies has ...
Magugu John W., Feng Song, Huang Qiuqiong, Ototo Gilbert O   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Population models for Greater Snow Geese: a comparison of different approaches to assess potential impacts of harvest [PDF]

Animal Biodiversity and Conservation, 2004
Demographic models, which are a natural extension of capture-recapture (CR) methodology, are a powerful tool to guide decisions when managing wildlife populations.
Gauthier, G., Lebreton, J.-D.
doaj  

Generalised Born-Infeld models, Lax operators and the T T ¯ $$ \mathrm{T}\overline{\mathrm{T}} $$ perturbation

Journal of High Energy Physics, 2018
Surprising links between the deformation of 2D quantum field theories induced by the composite T T ¯ $$ \mathrm{T}\overline{\mathrm{T}} $$ operator, effective string models and the AdS/CFT correspondence, have recently emerged.
Riccardo Conti, Leonardo Iannella, Stefano Negro, Roberto Tateo   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source