Results 151 to 160 of about 3,644,794 (274)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

The tree labeling polytope: A unified approach to ancestral reconstruction problems. [PDF]

Cell Syst
Schmidt H, Raphael BJ.
europepmc   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

From redundant association rules to product networks: A scalable confidence-improvement pruning and Maximum Spanning Tree approach. [PDF]

PLoS One
Đurišić V, Vujošević S, Kašćelan L, Vuković S.   +3 more
europepmc   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Independent Spanning Trees With Small Depths in Iterated Line Digraphs

, 1997
. We show that the independent spanning tree conjecture on digraphs is true if we restrict ourselves to line digraphs. Also, we construct independent spanning trees with small depths in iterated line digraphs.
Toru Hasunuma, Hiroshi Nagamochi
core  

Strigolactones: From Fundamental Biology to Applications in Tree Breeding. [PDF]

Physiol Plant
Ma Z, Li W, Guo Q, Tibesigwa DG, Meng Q, Wang F.   +5 more
europepmc   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Robust Branch-Cut-and-Price for the Capacitated Minimum Spanning Tree Problem over a Large Extended Formulation [PDF]

This paper presents a robust branch-cut-and-price algorithm for the Capacitated Minimum Spanning Tree Problem (CMST). The variables are associated to q-arbs, a structure that arises from a relaxation of the capacitated prize-collecting arbores- cence ...
Pessoa, Artur, Uchoa, Eduardo, Fukasawa, Ricardo, Poggi de Aragão, Marcus, Andrade, Diogo, Lysgaard, Jens   +5 more
core  

Decoupling between activation time and steady-state level in input-output responses. [PDF]

PLoS Comput Biol
Ravanelli G, Nam KM, Gunawardena J, Martinez-Corral R.   +3 more
europepmc   +1 more source