Results 101 to 110 of about 3,926 (185)

Multicenter experience using tofacitinib for treatment of refractory pediatric inflammatory bowel diseases in the United States

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Tofacitinib is a selective Janus kinase (JAK‐1) inhibitor approved for the treatment of ulcerative colitis (UC) in adults. Data is limited in the pediatric population. The aim of this study was to evaluate the efficacy of tofacitinib in pediatric inflammatory bowel disease (IBD).
Denise D. Young   +10 more
wiley   +1 more source

Long‐term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID pédiatrique multicenter study

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet   +18 more
wiley   +1 more source

Responsible laboratory surveillance of pediatric patients with inflammatory bowel disease on biologic infusion therapy

open access: yesJPGN Reports, EarlyView.
Abstract The annual healthcare spending on pediatric inflammatory bowel disease (IBD) has increased over time. The objectives of the study were to investigate the cost of routine laboratory surveillance in pediatric IBD patients during outpatient maintenance biologic infusions and determine their impact on clinical management.
Tanmai Shah   +3 more
wiley   +1 more source

Holocene sea‐level and environmental changes on the Isle of Mull, Scotland

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Sea‐level and coastal changes are reconstructed on the Isle of Mull, western Scotland, from 10 988 to 10 507 cal BP to the present. This research has produced the first SLIP for the Isle of Mull. A multiproxy approach including pollen, spore, foraminifera and diatom analyses reveals palaeoenvironmental changes from two coastal sites.
Katherine A. Selby   +6 more
wiley   +1 more source

Reconstructing post‐crisis recovery in the hinterlands of Constantinople: A high‐resolution first‐millennium CE pollen record from Lake Yeniçağa (NW Türkiye)

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Facing a novel plague pandemic, military invasions, and political–economic transformations, societies of the eastern Roman (Byzantine) empire had to adapt to a variety of pressures and new ways of exploiting their natural environments during the mid‐1st millennium CE.
Cristiano Vignola   +7 more
wiley   +1 more source

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