Results 171 to 180 of about 115,634 (274)

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

open access: yesEpilepsia, EarlyView.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt   +17 more
wiley   +1 more source

The Unbearable Indefiniteness of Spacetime. [PDF]

open access: yesFound Phys
Cinti E, Mariani C, Sanchioni M.
europepmc   +1 more source

Coupled Clustering in Hierarchical Matrices for the Oseen Problem

open access: yesInternational Journal for Numerical Methods in Fluids, EarlyView.
Fluid flow problems can be modelled by the Navier‐Stokes or, after linearization, by the Oseen equations. Their discretization results in linear systems in saddle point form which are typically very large and need to be solved iteratively. We propose a novel block structure for hierarchical matrices which is then used to build preconditioners for the ...
Jonas Grams, Sabine Le Borne
wiley   +1 more source

The impact of time‐to‐recurrence on post‐recurrence mortality in stage I–III colorectal cancer: A nationwide Danish cohort study

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) recurrence is a significant threat to survival despite surgery with curative intent. The characteristics of CRC recurrence, however, remain poorly understood, challenging postoperative surveillance. This study investigated post‐recurrence mortality and associations between time‐to‐recurrence and mortality among stage
Jesper Nors   +3 more
wiley   +1 more source

Alternative Price Dynamics and Valuation of Flexible Strategies

open access: yesInternational Journal of Finance &Economics, EarlyView.
ABSTRACT In this article, we study the optimal operational strategy of production projects. We investigate different underlying price models and determine the optimal barriers of transition to suspension, recovery, or irreversible abandonment of productive activity.
Cristina Bertolosi   +2 more
wiley   +1 more source

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