Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Novel insights on association and reactivity of Bispectral Index, frontal electromyogram, and autonomic responses in nociception- sedation monitoring of critical care patients [PDF]
, 2022 Juhani A. Stewart +3 more
openalex +1 more source
4d Index to 3d Index and 2d TQFT
, 2012 We compute the 4d superconformal index for N=1,2 gauge theories on S^1 x L(p,1), where L(p,1) is a lens space. We find that the 4d N=1,2 index on S^1 x L(p,1) reduces to a 3d N=2,4 index on S^1 x S^2 in the large p limit, and to a 3d partition function ...
Francesco Benini +3 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Comparison of the accuracy of two different modes of continuous cardiac index measurement following rapid volume infusion [PDF]
, 2005 Christoph Wiesenack +5 more
openalex +1 more source
Effects of Waste Sanitation Facilities on Water Quality Index and Human Health Risk Assessment of Groundwater Resources in Abeokuta Markets, Southwestern Nigeria [PDF]
, 2022 Adewale M. Taiwo +5 more
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Eccentric connectivity index [PDF]
, 2010 The eccentric connectivity index $\xi^c$ is a novel distance--based molecular structure descriptor that was recently used for mathematical modeling of biological activities of diverse nature. It is defined as $\xi^c (G) = \sum_{v \in V (G)} deg (v) \cdot
Ilić, Aleksandar
core