Results 131 to 140 of about 3,720,958 (247)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Long-term prophylaxis in hereditary angioedema: Real-world treatment patterns and healthcare resource utilization. [PDF]

World Allergy Organ J
Tachdjian R, Soteres DF, O'Connor M, Maheshwari C, Sehgal A, Wang A, Audhya PK, Craig TJ.   +7 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The quality of artificial grasslands in alpine regions is controlled by crop photosynthesis under different fertilization conditions. [PDF]

Sci Rep
Feng TX, Li F, Lin WS, Zhang L, Xiang XM, Wei XJ, De KJ.   +6 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Phenotypic characterization of Landim and Pafúri goat populations in Southern Mozambique based on morpho-structural traits and zoometric indices. [PDF]

PLoS One
Culhe DT, Matola MF, Muatareque E, Morrombe MP, Manhique MA, Tseu RJ, Changule AP, Taela MDG, Bila CG, Garcia-Herreros M.   +9 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Single point insulin sensitivity estimator index and incident impaired fasting glucose in Chinese adults: a retrospective cohort study. [PDF]

Front Endocrinol (Lausanne)
Yang D, Lin R, Li S, Ye S, Luo Z, Zhang H, Wu S, Zhang L.   +7 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Association between TyG index, TG/HDL-C ratio and coronary heart disease risk in elderly postmenopausal women: a retrospective cohort study. [PDF]

PeerJ
Wen W, Ye Q, Zhang L.
europepmc   +1 more source