Results 141 to 150 of about 714,452 (294)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Deep Learning Empowered Signal Detection for Spatial Modulation Communication Systems
MathematicsIndex modulation (IM) has attracted increasing research attention in recent years. Spatial modulation (SM) as a popular IM scheme is effective to increase spectral efficiency using the antenna index to transmit extra information bits. It can also address
Shaopeng Jin +2 more
doaj +1 more source
Analysis of Long Period Gratings Inscribed by CO2 Laser Irradiation and Estimation of the Refractive Index Modulation. [PDF]
Sensors (Basel), 2020 Rocha AM +4 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Tongxin xuebaoGiven the issues of low transmission rate and poor bit error performance in traditional differential chaos shift keying systems, a dual-mode three-dimensional index modulation differential chaos shift keying (DMTD-IM-DCSK) system was proposed.
HE Lifang, WU Xinggen, XUE Yansong
doaj
An RIS-Assisted Integrated Deep Learning Framework for MIMO-OFDM-IM
IEEE AccessMultiple-input multiple-output orthogonal frequency division multiplexing with index modulation (MIMO-OFDM-IM) offers a flexible trade-off between error performance and spectral efficiency.
Md Abdul Aziz +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source