Results 241 to 250 of about 4,542,507 (296)

Genetically proxied glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor pathway modulation is associated with favorable aging phenotypes: a drug-target Mendelian randomization study. [PDF]

Cardiovasc Diabetol
Li J, Li J, Xu X, Wang N, Lu Y, Wang B.
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Wireless Power and Data Transfer over Inductive Links for Biomedical Applications: Recent Advances, Challenges, and Limitations. [PDF]

Micromachines (Basel)
Ullah N, Barakat A, Kanaya H.
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

ATR Analysis: Quantifying Molecular and Bulk Responses in Guest-Host Poled Polymers with Push-Pull Heptamethine Chromophores. [PDF]

J Phys Chem B
Lyu D, Zhang D, Luo J.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Dosimetric comparison of pipe-joint versus conventional VMAT for lattice radiotherapy in bulky tumors: a retrospective planning study. [PDF]

Radiat Oncol
Zhong C, Xu M, Dong S, Xu C, Jiang Z, Yu H, Dai Z.   +6 more
europepmc   +1 more source

Mid-IR light modulators enabled by dynamically tunable ultra-high-Q silicon membrane metasurfaces. [PDF]

Nat Commun
Brikh FU, Ezerskii A, Pashina O, Glebov N, Yang W, Yin W, Makarov SV, Petrov M, Sinev I, Altug H.   +9 more
europepmc   +1 more source

Dual Modulation of Prostaglandin E2 Receptors EP3 and EP4 Protects β-Cell Mass in a Model of Aggressive Autoimmune Inflammation. [PDF]

Diabetes
Burkett JB, Fuhr J, Falk AC, Dadi P, Del Bene AN, Lucerne A, McNitt D, Clark LM, Maxwell M, Gaeth V, Allen K, Jacobson D, Moore DJ, Wilson CS, Gannon M.   +14 more
europepmc   +1 more source