Results 61 to 70 of about 6,942,383 (265)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Recent Results From the EU POF-PLUS Project: Multi-Gigabit Transmission Over 1 mm Core Diameter Plastic Optical Fibers [PDF]

, 2011
Recent activity to achieve multi-gigabit transmission over 1 mm core diameter graded-index and step-index plastic optical fibers for distances up to 50 meters is reported in this paper.
Gaudino, R., Yang, H., R. Kruglov, Tangdiongga E., Koonen A. M. J., Kruglov R., R. Gaudino, Ziemann, O., Visani, D., Greiss, I., Yang H., VISANI, DAVIDE, Loquai S., Ouzzif, M., E. Tangdiongga, O. Ziemann, Ziemann O., Tangdiongga, E., I. Greiss, Kruglov, R., C. M. Okonkwo, S. Loquai, B. Charbonnier, Kruglov, R, Loquai, S., Visani D., Tangdiongga, E.; id_orcid, M. Ouzzif, Greiss, I, Okonkwo, C.M.; id_orcid, Charbonnier, B., A. M. J. Koonen, Charbonnier, B, Charbonnier B., Okonkwo, C.M., H. Yang, Koonen, A.M.J., Greiss I., Gaudino, Roberto, D. Visani, Ouzzif M., Okonkwo C. M.   +41 more
core   +1 more source

Dual-mode index modulation aided OFDM with generalized prefix [PDF]

, 2019
Recently, a dual-mode OFDM relying on index modulation (DM-OFDM-IM) has been introduced to increase the data rate of the conventional IM based OFDM techniques.
Aldırmaz Çolak, Sultan, Cooklev, Todor, ACAR, YUSUF   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Spectral Efficient Spatial Modulation Techniques

IEEE Access, 2019
Space modulation techniques (SMTs) have emerged as promising candidates for spectral- and energy-efficient wireless communication systems since they strike a good balance among error performance, power efficiency, spectrum efficiency, and receiver ...
Hany S. Hussein, Mohamed Elsayed, Usama Sayed Mohamed, Hamada Esmaiel, Ehab Mahmoud Mohamed   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Modulation of Host Immunity by Targeting Gut Microbiota

, 2019
Intestinal microbiota plays a critical role in the modulation of human health. Dysregulation of the commensal flora is closely linked to functional changes of the immune system and subsequently contributes to development of immune disorders.
IM, SIN HYEOG
core