Results 181 to 190 of about 2,505,256 (301)

Construction of an index system for workplace services by family doctors in China: a two-round Delphi study. [PDF]

BMC Prim Care
Guo J, Yu J, Guo J, Xiao J, Yan X, Liang H, Qian Y, Huang J.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Evaluation and Strategic Pathways for Smart Marine City Development in Shandong Province

Haiyang Kaifa yu guanli
In the new journey of accelerating the construction of a maritime power, smart marine cities have become key drivers of high-quality marine economic development.
WAN Xiaole, LI Chenyang, MAO Jinyue, ZHANG Shihai   +3 more
doaj  

Construction of an index system for assessing emergency department overcrowding in Chinese tertiary hospitals: a Delphi study. [PDF]

BMC Emerg Med
Ren Z, Xu N, Yang Y, Li S, Zhang H, Wang L, Mu YN, Chong W, Zhou P, Pan L, Wang G, Li X, Li Y, Liu W, Liu H, Xu B, Jin Y, Ma L, Feng G, Ma Q.   +19 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Construction of Quality Evaluation Index System for Surgical Positioning: A Delphi Method. [PDF]

Nurs Open
Guo Y, Qu X, Zhao T, Wang Y.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Construction of a core competence index system for undergraduate anesthesia nursing graduates: a Delphi and Analytic Hierarchy Process. [PDF]

BMC Nurs
Yin X, Wang L, Han J, Li Q, Tu S, Mao Y, Wang S, Hu H, Zhou F.   +8 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Development, Validation and Primary Application of a Competency-Based Training Course Index System for Gynaecological Specialist Nurses in China: A Mixed-Methods Study. [PDF]

Nurs Open
Liu D, Peng X, Xiong T, Bu P.
europepmc   +1 more source