Results 91 to 100 of about 9,478,717 (296)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 1916 This is volume 35 of the College of Wooster’s Index collection. The Index is the college’s yearbook, it includes an annual record of events at Wooster. This edition was published by the class of 1916.
Index Editors,
core +1 more source
An Automated Chronic Disease Management for Cardiac Arrest Detection and Prevention on Emergency usingInternet of Medical Things (IoMT) [PDF]
E3S Web of ConferencesThe Internet of Medical Things (IoMT) is a world of interconnected things that can sense, stimulate, and collaborate with one another and with the environment. Heart attacks have become more common in recent years, putting people's lives at risk. However,
S. Sarumathi +3 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Trade-off between the number of index-terms and the information retrieval system’s performance
Kuwait Journal of Science, 2017 Performance of modern day information retrieval (IR) systems depends on the index terms and their occurrence frequency. Hence, a small variation in the frequency of index terms alters the performance of IR systems. This article analyzes the variation in
Lakshmi Srinivasa Rengan +2 more
doaj
Cloud Computing Based Intelligent Video Surveillance Framework for Logistics Security
IEEE AccessLogistics services facilitate the worldwide movement of products via interconnected vehicle networks. The flow of commodities is tracked to ensure security, optimization, and safety, among other utilities.
Omar Alruwaili +4 more
doaj +1 more source
A new national index of consumer prices and 10 years of the HICP [PDF]
To mark the introduction, in January 2006, of a new national index of consumer prices (NICP) in Belgium and almost 10 years of application of the harmonised index of consumer prices (HICP) at the European level, the article highlights recent ...
D. Cornille
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