Results 91 to 100 of about 372 (252)

Whittle Index for Partially Observed Binary Markov Decision Processes

open access: yes, 2017
We consider the problem of dynamically scheduling M out of N binary Markov chains when only noisy observations of state are available, with ergodic (equivalently, long run average) reward.
Borkar, Vivek S., Vivek S. Borkar
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

RESTLESS BANDIT MARGINAL PRODUCTIVITY INDICES II: MULTIPROJECT CASE AND SCHEDULING A MULTICLASS MAKE-TO-ORDER/-STOCK M/G/1 QUEUE [PDF]

open access: yes
This paper develops a framework based on convex optimization and economic ideas to formulate and solve approximately a rich class of dynamic and stochastic resource allocation problems, fitting in a generic discrete-state multi-project restless bandit ...
José Niño-Mora
core  

Dynamic priority allocation via restless bandit marginal productivity indices

open access: yes
Priority allocation, Stochastic scheduling, Index policies, Restless bandits, Marginal productivity index, Indexability, Dynamic control of queues, Control by price, 90B36, 90C40, 90B05, 90B22, 90B18,
José Niño-Mora
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Index.

open access: yesJournal of the Linnean Society of London, Zoology, 1870
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +2 more sources

Essays on indexability of stochastic sheduling and dynamic allocation problems

open access: yes
In this Thesis, we first deploy Gittins index theory to establish the indexability of inter-alia general families of restless bandits that arise in problems of stochastic scheduling with switching penalties and machine maintenance. We also give formulae
Ruíz Hernández, Diego
core  

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