Results 41 to 50 of about 372 (252)
Two-Armed Restless Bandits with Imperfect Information: Stochastic Control and Indexability
, 2018 We present a two-armed bandit model of decision making under uncertainty where the expected return to investing in the “risky arm” increases when choosing that arm and decreases when choosing the “safe” arm.
Roland Fryer, Philipp Harms
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Journal of the Linnean Society of London, Zoology, 1896 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +2 more sources
Characterization and computation of restless bandit marginal productivity indices [PDF]
The Whittle index [P. Whittle (1988). Restless bandits: Activity allocation in a changing world. J. Appl. Probab. 25A, 287-298] yields a practical scheduling rule for the versatile yet intractable multi-armed restless bandit problem, involving the ...
Jose Nino-Mora
core
A generalised gittins index for a class of multi-armed bandits with general resource requirements [PDF]
, 2009 We generalise classical multiarmed bandits to allow for the distribution of a (fixed amount of a) divisible resource among the constituent bandits at each decision point.
Minty, John +3 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Two-stage index computation for bandits with switching penalties II : switching delays [PDF]
This paper addresses the multi-armed bandit problem with switching penalties including both costs and delays, extending results of the companion paper [J. Niño-Mora.
Jose Nino-Mora
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Estimating the Indexability of Multimedia Descriptors for Similarity Searching
, 2010 cote interne IRCAM: Barton10aInternational audienceEstimating the Indexability of Multimedia Descriptors for Similarity ...
Charbuillet, Christophe +4 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source