Results 121 to 130 of about 1,355,032 (346)

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Bipartite network structures and individual differences in sound change

open access: yesGlossa, 2019
This paper assesses the influence of social network structure, and the role of the individual, in shaping the loss of the regional vowel system in the Southern U.S. city of Raleigh, North Carolina.
Robin Dodsworth
doaj   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Orthographic variation < Macau>/ and Macau identity

open access: yesCogent Arts & Humanities
This study examines the orthographic variation between the place name  and  in English texts in Macau and its interaction with social factors. Using Sebba’s framework of Orthographic Regimes, a statistical analysis was conducted to explore the usage of ...
Trin Qingyi Chen, Brian Hok-Shing Chan
doaj   +1 more source

Editorial: Data perceptualization for climate science communication. [PDF]

open access: yesFront Psychol, 2023
Lindborg P, Chopra SS, Groß-Vogt K.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Humble primary intensions: fixing two-dimensional semantics [PDF]

open access: yes, 2013
Certain problems with standard two-dimensional semantics are addressed and cases in which these problems arise explored. In such cases the primary intension cannot be univocally mapped in one and only one indexical world, thus standard two-dimensional ...
Fabiano, Joao
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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