Results 131 to 140 of about 1,355,032 (346)
CLIMATE CHANGE AS SECOND-HAND KNOWLEDGE: ON THE SOCIAL EPISTEMOLOGY OF A SCIENTIFIC CONCEPT
International Journal of Social and Educational InnovationThe issue of climate change has been ubiquitous in media discourse in recent decades. Having become a subject of common knowledge, the concept is commonly used outside the strict domain of environmental science, affecting the way human communities ...
Lucian MOCREI-REBREAN
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Situating Language in the Real-World: The Role of Multimodal Iconicity and Indexicality. [PDF]
J Cogn, 2021 Murgiano M, Motamedi Y, Vigliocco G.
europepmc +1 more source
Aboutness: Towards Foundations for the Information Artifact Ontology [PDF]
, 2015 The Information Artifact Ontology (IAO) was created to serve as a domain‐neutral resource for the representation of types of information content entities (ICEs) such as documents, data‐bases, and digital im‐ages. We identify a series of problems with the
Ceusters, Werner, Smith, Barry
core
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Political Discourse Approach Applied the Current Study Issue Occurred [PDF]
, 2017 The research was to aim at approaching a political discourse as an effort to solve the issues. News reporting assigns meaning to issues by providing a continuous record of public events and visibility to the claims of actors.
Vurly, M. E. (Mike) +1 more
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Pointing to the Future of Language Research. [PDF]
J Cogn, 2021 Long M, Chia K, Kaschak MP.
europepmc +1 more source