Results 111 to 120 of about 3,250,923 (288)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Assessing the use of Geographical Indications for the New England wine region in NSW [PDF]

Geographical Indications (GIs) have increasingly been used as a marketing tool to create an image of quality and uniqueness, and so capture premium prices.
Campbell, Gene, Chang, Hui-Shung (Christie), Sniekers, Peter   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Impact of Tracheostomy Indication on Patient Outcomes and Hospital Course

Laryngoscope Investigative Otolaryngology
Objective The purpose of this study is to better understand the prognostic implications for a patient's hospital course, chances for ventilator liberation and decannulation, functional status, and mortality based on the indication for tracheostomy ...
Ryan C. Higgins, Kaeli Samson, Duncan Works, Jayme R. Dowdall   +3 more
doaj   +1 more source

Hanefî Fıkhında ve Usûlünde Sözün Mûcebi-Muhtemeli Ayırımı

Rize İlahiyat Dergisi
Gerek fıkıh usûlü gerekse fürû-ı fıkıh kaynaklarının ilgili bahislerinde, lafızlardan ve sözlerden anlaşılan manaların İslam hukukçularınca en genel şekliyle “sözün mûcebi” ve “sözün muhtemeli” olmak üzere iki sınıf olarak kategorize edildiği ...
Üveys Ateş
doaj   +1 more source

The Affordable Care Act and the Change in Voluntary Part-time Employment by States [PDF]

, 2017
A major goal of the ACA was to give workers the ability to obtain insurance outside of their employment, so that they would not be tied to a job that doesn't meet their needs or fully utilize their skills due of their need for health insurance.
Cherrie Bucknor, Dean Baker
core  

A Preliminary Indication of Evolution of Type Ia Supernovae from their Risetimes

, 1999
We have compared the risetime for samples of nearby and high-redshift type Ia supernovae (SNe Ia). The fiducial risetime of the nearby SNe Ia is 2.5+/-0.4 days longer than the proemial risetime determined by Goldhaber (1998a,b) for high-redshift SNe ...
Adam G. Riess, Alexei V. Filippenko, Brian P. Schmidt, Goldhaber G., Groom D. E., Jha S., Weidong Li   +6 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source