Results 81 to 90 of about 4,059,966 (338)

Global first-in-class drugs approved in 2023–2024: Breakthroughs and insights

The Innovation
First-in-class (FIC) drugs are considered the main drivers of new drug discovery and have novel targets and mechanisms. The proportion of FIC drugs among new drugs provides fundamental guidance for both academic and pharmaceutical research. From a global
Daichao Zhai, Qiuyue Zhang, Xiaoling Lu, Qidong You, Lei Wang   +4 more
doaj   +1 more source

Maternal complications and cesarean section without indication: systematic review and meta-analysis

Revista de Saúde Pública, 2017
OBJECTIVE The objective of this study was to determine the risks of severe acute maternal complications associated with cesarean section without medical indication. METHODS A systematic review was carried out with meta-analysis. The literature search was
Keila Cristina Mascarello, B. Horta, M. Silveira   +2 more
semanticscholar   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Radiotherapy in langerhans cell histiocytosis : a rare indication in a rare disease [PDF]

, 2013
Introduction: Langerhans Cell Histiocytosis (LCH) represents a rare benign disorder, previously designated as "Histiocytosis X", "Type II Histiocytosis" or "Langerhans Cell Granulomatosis".
Bruns, Frank, Büntzel, Jens, Eich, Hans Theodor, Haverkamp, Uwe, Heyd, Reinhard, Kriz, Jan, Micke, Oliver, Schäfer, Ulrich, Seegenschmiedt, Heinrich   +8 more
core   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

The Role of Anti-Plague Institutions in Provision of the Epidemiological Well-Being During the Preparation and Carrying out of the APEC 2012 Summit

Проблемы особо опасных инфекций, 2013
Summarized are the results of the work on provision of sanitary and epidemiological well-being during the arrangement and carrying out the APEC Summit on the Russky Island.
S. V. Balakhonov, E. I. Andaev, M. V. Chesnokova, A. V. Allenov, T. V. Khomenko, L. I. Ivanov, A. Ya. Nikitin, S. A. Kosilko, A. G. Koval’Sky, E. S. Kulikalova   +9 more
doaj   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Legionellosis Agent Indication Using Immunochromatography with Visual and Digital Video Detection

Проблемы особо опасных инфекций, 2009
Proposed was the immunochromatographic express-test for legionellosis agent detection in water environment. The method is high-sensitive and specific allowing to detect only first serogroup of legionellosis agent.
S.P. Yarkov, S.I. Tret`yakov, L.A. Basharova, A.N. Brovkina, V.N. Zlobin, I.S. Tartakovskiy   +5 more
doaj   +1 more source

Estimating the prevalence of unpaid adult care over time [PDF]

, 2005
To help fulfil their responsibilities towards unpaid carers, service providers need some idea of the carer’s situation and how many might require support.
Hirst, Michael Anthony
core  

Fine tuning as an indication of physics beyond the MSSM

, 2010
We investigate the amount of fine tuning of the electroweak scale in the presence of new physics beyond the MSSM, parametrized by higher dimensional operators.
Antoniadis, Barate, Barbieri, Barbieri, Barbieri, Batra, Bellazzini, Blum, Carena, Casas, Casas, Chankowski, Chankowski, D.M. Ghilencea, de Boer, Dermisek, Dimopoulos, Dimopoulos, Dine, Espinosa, Espinosa, Espinosa, G.G. Ross, Ghilencea, Giudice, Ibanez, Ibanez, Ibanez, Ibanez, Ibanez, Ibanez, Kane, Maloney, Martin, Piriz, Polonsky, S. Cassel, Schael   +37 more
core   +1 more source