Results 221 to 230 of about 1,594,269 (319)

Does surgical indication influence implant survival in reverse shoulder arthroplasty? A comparative cohort study of fracture and glenohumeral osteoarthritis. [PDF]

Eur J Orthop Surg Traumatol
Nachtnebl L, Apostolopoulos V, Brančík P, Čechová R, Dajča M, Červeňák V, Martinek L, Mahdal M, Tomáš T.   +8 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Correction to: The evolving landscape of rheumatic drugs and their indications in paediatric and adolescent care. [PDF]

Rheumatology (Oxford)
europepmc   +1 more source

Improved outcomes after anterior vertebral tethering for AIS using ideal versus acceptable indications. [PDF]

Spine Deform
Braun JT, Federico SC, Lawlor DF, Croitoru DP, Grottkau BE.   +4 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Demographic and clinical characteristics of patients undergoing evisceration: a six-year retrospective study in a tertiary referral center. [PDF]

BMC Ophthalmol
Eroğul Ö, Kaşıkçı M.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Nationwide trends in paediatric pacemaker implantation in France, 2014-2024. [PDF]

Europace
Blacher J, Semenzato L, Dufour E, Rachas A, Zureik M, Olié V.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Surgical interventions in inflammatory bowel disease: Indications, techniques, outcomes, and future directions. [PDF]

World J Gastrointest Pharmacol Ther
Agrawal H, Gupta N.
europepmc   +1 more source