Results 91 to 100 of about 4,248,566 (303)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Evaluating the Management Effectiveness of the Marine Tourism Park in Eastern Bintan Island, Indonesia

Journal of Natural Resources and Environmental Management
Marine Tourism Park in the Eastern Region of Bintan Island (Bintan MPA) is located in Bintan Regency, Riau Islands Province. This marine protected area (MPA) covers a total area of 1,385.61 km2. In 2014, due to the implementation of a new government law,
Bagus Bagaskoro, Eka Intan Kumala Putri, Wonny Ahmad Ridwan   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The structure of the deferred income tax and its influence on indicators describing the economic performance of commercial insurance companies

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2007
The main objective of this paper is presentation of findings gathered through an analysis of items that cause deferred income tax in commercial insurance companies in the Czech insurance market. The evaluation of the subject is focused in accordance with
Hana Bohušová, Eva Vávrová
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Leaf and must nitrogen content two complementary indicators of grapevine nitrogen status

OENO One, 2003
Grapevine nitrogen status was assessed by nitrogen content in leaf blade and petiole at veraison, in must at harvest and in pruned wood in December.
Jean-Pierre Gaudillère, Eric Chantelot, Jean-Pierre Soyer, Ch. Molot, Sylvie Milin   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

ASSESSMENT OF NATIONAL ECONOMIC SECURITY OF UKRAINE

Фінансово-кредитна діяльність: проблеми теорії та практики
The purpose of the article is to build an assessing model for national economic security and to assess the national economic security of Ukraine during 2019–2021. The concept of national economic security is examined.
Ganna Kozachenko , Andriy Didyk, Yuriy Pogorelov, Yuliia Romanovska , Maksym Marmura   +4 more
doaj   +1 more source

A new modal-based damage location indicator [PDF]

, 2014
Vibration-based damage detection techniques use the change in modal data as an indicator to assess damages in the structure. Knowing the structural dynamic characteristics of the healthy and damaged structure, the estimation of the damage location and ...
Abdel Wahab, Magd, Furdui, H., Gillich, G.R., Praisach, Z.I.   +3 more
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