Results 141 to 150 of about 4,248,566 (303)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Nonconventional Technologies Review, 2016 The paper referes to the possibility of using neural networks in selecting the “R&D” strategy, in the nonconventional technologies field, presenting a selection and the main key elements of the Research and Development (R & D) strategies, applicable in ...
Simona Ioana Marinescu +1 more
doaj
, 2016 The aim of the essay is to survey the main issues raised by global indicators, and to critically review the state of the art of the field’s literature. For this purpose, the chapter begins by defining global indicators and by placing their historical rise in the wider cultural context of the increasing power of quantitative knowledge over the past two ...
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
An insight into two decades of Skilled Birth Attendants in Nepal
Frontiers in Global Women's Health, 2022 Shreyashi Aryal, Samata Nepal
doaj +1 more source
Novel Psychometric Indicator Assessments: The Relative Excess Correlation and Associated Matrices. [PDF]
EpidemiologyVanderWeele TJ, Padgett RN.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Assessing Recreational Safety of Urban Marine Waters: Long-Term Coliform and Enterococcus Analysis. [PDF]
Water Environ ResRingenary MJ, Tanacredi JT, Frame GW.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source