Results 51 to 60 of about 152,483 (320)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

DB4US: A Decision Support System for Laboratory Information Management

open access: yesInteractive Journal of Medical Research, 2012
BackgroundUntil recently, laboratory automation has focused primarily on improving hardware. Future advances are concentrated on intelligent software since laboratories performing clinical diagnostic testing require improved information systems to ...
Carmona-Cejudo, José M   +6 more
doaj   +1 more source

Aggregating multiple body sensors for analysis in sports [PDF]

open access: yes, 2008
Real time monitoring of the wellness of sportspersons, during their sporting activity and training, is important in order to maximise performance during the sporting event itself and during training, as well as being important for the health of the ...
Diamond, Dermot   +8 more
core  

Controlling the variable of pressure in the production of test footwear impressions [PDF]

open access: yes, 2012
Footwear impression lifting and enhancement techniques may be affected by several variables introduced during the production of test footwear impressions, thus limiting the usefulness of enhancement technique comparisons and the results obtained.
Bandey, Helen   +4 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Chemical enhancement of soil based footwear impressions on fabric [PDF]

open access: yes, 2012
This study investigates the enhancement of footwear impressions prepared with soils from different locations on a variety of fabric surfaces with different morphology.
Bandey, Helen   +3 more
core   +3 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

A Review of Impact Assessment Indicators of Medical Research

open access: yesمدیریت اطلاعات سلامت, 2017
The aim of investment in health research is improvement of the state of policy-making, allocation of resources, practical application of research results, and improvement of public health.
Mansoureh Feizabadi   +4 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Complex microscopic express-analysis for biomedical full-scale investigation [PDF]

open access: yesСаратовский научно-медицинский журнал, 2013
To perform biomedical full-scale investigation there had been developed a set of microscopic analysis of histologi-cal preparations. This complex includes cryotome for histological sections, a set of chemical reagents and laboratory glassware for ...
Datsenko A.M., Kazmin V.I.
doaj  

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