Results 51 to 60 of about 147,811 (320)
FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
A Review of Impact Assessment Indicators of Medical Research
مدیریت اطلاعات سلامت, 2017 The aim of investment in health research is improvement of the state of policy-making, allocation of resources, practical application of research results, and improvement of public health.
Mansoureh Feizabadi +4 more
doaj
Current, emerging and future technologies for sensing the environment [PDF]
, 2009 This paper reviews current technologies that are used for environmental monitoring, and presents emerging technologies that will dramatically improve our ability to obtain spatially distributed, real-time data about key indicators of environmental ...
Diamond, Dermot
core
Pyrimido[1,2-a]-purin-10(3H)-one, M(1)G, is less prone to artifact than base oxidation [PDF]
, 2005 Pyrimido[1,2-a]-purin-10(3H)-one (M(1)G) is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose.
Jeong, Yo-Chan +3 more
core +3 more sources
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Complex microscopic express-analysis for biomedical full-scale investigation [PDF]
Саратовский научно-медицинский журнал, 2013 To perform biomedical full-scale investigation there had been developed a set of microscopic analysis of histologi-cal preparations. This complex includes cryotome for histological sections, a set of chemical reagents and laboratory glassware for ...
Datsenko A.M., Kazmin V.I.
doaj
Creation and study of formulations as inhibitors of metal corrosion and scaling for stabilization water treatment in water utilization systems (a review) [PDF]
, 2016 This review summarizes studies for the past 5 years aimed at creation of efficient organophosphonate reagents for the stabilization water treatment aimed at preventing metal corrosion and scaling in water utilization systems.This study was carried out ...
Bolt, Y. V. +4 more
core
Chemical enhancement of soil based footwear impressions on fabric [PDF]
, 2012 This study investigates the enhancement of footwear impressions prepared with soils from different locations on a variety of fabric surfaces with different morphology.
Bandey, Helen +3 more
core +3 more sources
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source