Results 51 to 60 of about 153,076 (312)

Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii [PDF]

, 2015
© 2015 Elsevier Inc. Fossil fuel emissions and changes in net land use lead to an increase in atmospheric CO 2 concentration and a subsequent decrease of ocean pH. Noticeable effects on organisms' calcification rate, shell structure and energy metabolism
Hardege, Jörg D., Lerebours, Adelaide, Rotchell, Jeanette M., Wäge, Janine   +3 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Intersex related gene expression profiles in clams Scrobicularia plana : molecular markers and environmental application [PDF]

, 2015
Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K.
Alvarez-Munoz, Diana, Ciocan, Corina, Ciocan, Corina M., Cornelius, Keith, Cubero-Leon, Elena, Hill, E. M., Hill, Elizabeth, Indiveri, Paolo, Langston, William, Langston, William J., Lerebours, Adelaide, Minier, Christophe, Pope, Nick, Rotchell, Jeanette, Rotchell, Jeanette M.   +14 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Review of Impact Assessment Indicators of Medical Research

مدیریت اطلاعات سلامت, 2017
The aim of investment in health research is improvement of the state of policy-making, allocation of resources, practical application of research results, and improvement of public health.
Mansoureh Feizabadi, Fatemeh Fahimnia, Nader Naghshineh, Shahram Tofighi, Alireza Mosavi -Jarrahi   +4 more
doaj  

The use of life cycle assessment as an early R&D decision tool: bottlenecks and potential solutions [PDF]

, 2014
At an ever increasing rate innovative chemistry and technology platforms are reshaping manufacturing environments to become factories of the future as being more productive, lean and flexible.
De Meester, Steven, De Soete, Wouter, Debaveye, Sam, Dewulf, Jo, Heirman, Bert   +4 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Complex microscopic express-analysis for biomedical full-scale investigation [PDF]

Саратовский научно-медицинский журнал, 2013
To perform biomedical full-scale investigation there had been developed a set of microscopic analysis of histologi-cal preparations. This complex includes cryotome for histological sections, a set of chemical reagents and laboratory glassware for ...
Datsenko A.M., Kazmin V.I.
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source