Results 91 to 100 of about 3,838,934 (281)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
REFLECTIONS OF THE EU EXCISES POLICY ON DYNAMICS OF ASSOCIATION OF BIH IN LIGHT OF GLOBAL CHALLENGES
Acta Economica, 2009 Dedication of Bosnia and Herzegovina to European integrations requires a fulfilment of pre-accession obligations that relate to harmonization on excises taxation in BiH with the EU standards.
Динка Антић, PhD
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Indian Journal of Community MedicineIndia ranks second in the world after China with 74.2 million living with diabetes currently and is projected to see 124.9 million living with diabetes by 2045.
Lingareddy Prathyusha +4 more
doaj +1 more source
Coherent control of indirect excitonic qubits in optically driven quantum dot molecules
, 2010 We propose an optoelectronic scheme to define and manipulate an indirect neutral exciton qubit within a quantum dot molecule. We demonstrate coherent dynamics of indirect excitons resilient against decoherence effects, including direct exciton ...
B. D. Bartolo +9 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Pursuit-evasion dynamics for Bazykin-type predator-prey model with indirect predator taxis
, 2023 P. Mishra, Dariusz Wrzosek
openalex +1 more source
Microsimulation of indirect taxes [PDF]
The goal of this paper is to simulate a tax shift from labour to consumption and perform a distributional analysis of the reform. Microsimulation programs are often uniquely focussed on the personal income tax system and on social security contributions ...
André Decoster +3 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Factors influencing the identification of it indirect costs: A case study [PDF]
, 2008 Organizations expenditure on Information technology (IT) related investments continue to rise in the face of the fierce competition in the various marketplaces.
Ghoneim, A
core