Results 31 to 40 of about 251,482 (258)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Assessment of Economic Burden and Quality of Life in Stable Coronary Artery Disease Patients

Indian Journal of Medical Specialities, 2019
Background: Coronary artery disease (CAD) is known to adversely impact the quality of life (QOL) of the patients and poses an economic burden to the family and society. However, the same has not been estimated in India. Objectives: To estimate the annual
Lalit Kumar, Anupam Prakash, S. K. Gupta
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Prevalence-Based Study to Estimate Cost of Illness of Rheumatoid Arthritis in a Tertiary Care Hospital in India

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Background: Rheumatoid arthritis (RA) is a chronic progressive inflammatory condition with high cost of management and significant impact on the patient and healthcare system.
Satish Kumar, Ankit Kumar, A. S. Menon, Seema Patrikar, Someshwar Gaikwad, S. K. Singh   +5 more
doaj   +1 more source

Financial cost of hypertension in urban and rural tertiary health facilities in Southwest, Nigeria: A comparative cross-sectional study

Indian Journal of Community Medicine, 2023
Background: The financial cost of hypertension could result in serious economic hardship for patients, their households, and the community. To assess and compare the direct and indirect cost of care for hypertension in urban and rural tertiary health ...
Tope Michael Ipinnimo, Eyitayo Ebenezer Emmanuel, Motunrayo Temidayo Ipinnimo, Kehinde Hassan Agunbiade, Oladipupo Adekunle Ilesanmi   +4 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Simulación técnica económica de dos sistemas de construcción de techumbre en el sureste de México Technical and economical simulation of two roofing construction systems in southeast Mexico

Revista Ingeniería de Construcción, 2009
El uso de prefabricados en la construcción aparentemente no es una alternativa económica si se le compara con métodos constructivos que hacen uso de mano de obra de manera intensiva en países en vías de desarrollo. En este trabajo se presentan un estudio
Julio R Baeza Pereyra, Sergio O Álvarez Romero   +1 more
doaj  

Determining direct, indirect healthcare and social costs for diabetic retinopathy management: a systematic review

BMC Ophthalmology
Introduction Diabetic retinopathy (DR) is a rapidly growing global public health threat; it affects 1 in 3 people with diabetes and is still the leading cause of blindness among the working-age population.
Mawdda Benhamza, Maznah Dahlui, Mas Ayu Said   +2 more
doaj   +1 more source

Indirect Costs and Cost-Effectiveness Analysis

Value in Health, 2006
This article examines the methodological implications of the societal perspective in cost-effectiveness analyses in which the costs of health-care interventions are defined as the sums of direct and indirect costs. In the model of cost-effectiveness analysis in which the planner distributes patients among many treatments for many illnesses, the ...
openaire   +2 more sources