Results 51 to 60 of about 2,406,313 (294)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Change-point estimation from indirect observations. 1. Minimax complexity [PDF]
, 2007 International audienceWe consider the problem of nonparametric estimation of signal singularities from indirect and noisy observations. Here by singularity, we mean a discontinuity (change-point) of the signal or of its derivative.
Tsybakov, Alexandre, B. +13 more
core +1 more source
Indirect estimation of elliptical stable distributions [PDF]
We present an indirect estimation approach for elliptical stable distributions which relies on the use of a multivariate t distribution as auxiliary model.
LOMBARDI, Marco, VEREDAS, David
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Simulation-based Estimation of Contingent-claims Prices [PDF]
A new methodology is proposed to estimate theortical prices of financial contingent-claims whose values are dependent on some other underlying financial assets. In the literature the preferred choice of estimator is usually maximum likelihood (ML).
Jun Yu, Peter C. B. Phillips
core +2 more sources
Evaluation of brick resistance to freeze / thaw cycles according to indirect procedures
Građevinar, 2014 The brick resistance was tested in the paper by direct method, and according to some indirect procedures presented in international literature and regulations.
Ivanka Netinger +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Low-Cost Sensors State Estimation Algorithm for a Small Hand-Launched Solar-Powered UAV
Sensors, 2019 In order to reduce the cost of the flight controller and improve the control accuracy of solar-powered unmanned aerial vehicle (UAV), three state estimation algorithms based on the extended Kalman filter (EKF) with different structures are proposed ...
An Guo, Zhou Zhou, Xiaoping Zhu, Fan Bai
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source