Results 251 to 260 of about 17,992 (316)

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

open access: yesiMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui   +9 more
wiley   +1 more source

Perception‐transduction‐transmission separation bionic H2S sensor

open access: yesInfoScience, EarlyView.
The modular separation of biological olfactory systems boasts unparalleled efficiency in olfactory recognition. Introducing this perception‐transduction‐transmission separation design into chemiresistive gas sensors (bionic olfactory sensing) based on the heterojunction rectification effect overcomes the inherent limitations of traditional sensor ...
Guoliang Lv   +6 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

open access: yesInterdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui   +12 more
wiley   +1 more source

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