Results 241 to 250 of about 7,518,852 (332)

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Small pond, big opportunities: rethinking social mobility through niche sports in Latin America. [PDF]

Front Sports Act Living
Chen O.
europepmc   +1 more source

Civic capital in unequal and uncertain times: individual, school, and contextual determinants

Ari Kim
openalex   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Drivers of fishermens'livelihood resilience and transitioning to ecological farming in Yangtze River,China:From PLS-SEM and fs/QCA. [PDF]

PLoS One
Wang X, Zheng J, Chen T.
europepmc   +1 more source

Polarization‐Multiplexed Metalens Enables Switchable and Compact Chromatic Confocal Sensing with Dual‐Mode Precision Control

Advanced Science, EarlyView.
This work breaks conventional design paradigms by leveraging a polarization‐multiplexed metasurface to create the first chromatic confocal sensor with dynamically switchable measurement performance, achieving 10‐fold miniaturization (Ø1 mm vs cm‐scale conventional probes).
Zhicheng Zhao, Yuting Jiang, Tao Lai, Wenxiang Peng, Yueqiang Hu, Shanyong Chen   +5 more
wiley   +1 more source

Neighborhood bonding and bridging social capital, social activity participation, and short-term cognitive variability in later life. [PDF]

J Gerontol B Psychol Sci Soc Sci
Hyun J, Cerino ES, Katz MJ, Lovasi G, Lipton RB, Sliwinski MJ.   +5 more
europepmc   +1 more source

Compact Optical Reservoir Computing via Luminescence Dynamics in Rare‐Earth Ions‐Doped Nanocrystals

Advanced Science, EarlyView.
A functionally compact optical reservoir computing platform is demonstrated using rare‐earth ion‐doped nanocrystals, whose intrinsic nonlinear luminescence dynamics and multi‐timescale metastable states provide nonlinear mapping and fading memory without bulky delays or resonant structures.
Junyan Chen, Jingsong Fu, Jie Xu, Yixiang Qin, Axin Du, Kaiyang Wang, Limin Jin, Can Huang   +7 more
wiley   +1 more source

Biomimetic Multiscale‐Structured Biomass Graphene/Polyurethane Sponge Composite for Flexible Pressure Sensors and Intelligent Cushioning Materials

Advanced Science, EarlyView.
In this study, a multifunctional conductive sponge composite (MAPU) is developed using a biomimetic, hierarchical construction strategy emulating the growth process of natural wood. This approach involved integrating biomass‐derived graphitic nanoflakes, synthesized from luffa vine (LVGN), into a polyurethane (PU) sponge matrix.
Runmin Xu, Pusen Cao, Tingting Zhang, Jie Wei, Yue Wang, Zhi Huang, Zhenghang Chen, Jianfeng Xi, Yong Guo, Yuxia Chen   +9 more
wiley   +1 more source