Results 51 to 60 of about 7,518,852 (332)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

From individual social capital to collective social capital: empirical evidence from inter-firm financing trust network

open access: yesThe Journal of Chinese Sociology, 2018
The paper proposes two theoretical hypotheses about how collective social capital is constructed based on the operation of individual social capital in Chinese context: the logic of particularist guanxi operations and the logic of social prestige ...
Bao Wu
doaj   +1 more source

Quality Management Systems and Working Capital SMEs in GPO—A Case of Poland

open access: yesAdministrative Sciences, 2020
Working capital is designed to provide enterprises with financial security. Its level depends on the strategy of managing individual elements of working capital. An appropriate management strategy allows companies to obtain added working capital. Working
Grzegorz Zimon, Dominik Zimon
doaj   +1 more source

The association of social capital with depression and quality of life in school-aged children.

open access: yesPLoS ONE, 2022
Social capital is an important factor that affects mental health. The purpose of this study was to examine the relationship between social capital and depression and between social capital and quality of life (QoL) in children in elementary and junior ...
Hiroyuki Mori   +6 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Effects of tourism CSR on employee psychological capital in the COVID-19 crisis: from the perspective of conservation of resources theory

open access: yesCurrent Issues in Tourism, 2020
The main purpose of this research was to illustrate how companies contributed to employee psychological capital in tourism during the COVID-19 crisis based on the conservation of resources theory (CoR). Psychological capital including self-efficacy, hope,
Yan Mao   +3 more
semanticscholar   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong   +7 more
wiley   +1 more source

Psychological capital, quality of life, and well-being in mother caregivers of individuals with down syndrome [PDF]

open access: gold, 2023
Alina Chiracu   +9 more
openalex   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song   +6 more
wiley   +1 more source

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