Results 171 to 180 of about 189,665 (265)

Effectiveness of Single-Component Clinician Reminder Systems for Smoking and Obesity Preventive Care in Primary Care: A Systematic Review. [PDF]

Cureus
Khormi MA, Alqahtani MA, Mujayri HM, Alzahrani AO, Alqarni GA, Alshehri RA, Alaklabi SS, Alharthi AW, Alharthi AO, Alharthi AO, Alshahrani AF, Zughlul MK.   +11 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Women's health across the reproductive lifespan in women with germline TP53 pathogenic variants: a clinical perspective. [PDF]

Oncologist
Halpern N, Bernstein-Molho R, Peerless Y, Kventsel I, Frenkel Z, Mizrachi Y, Shani H, Safrai M.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke. [PDF]

Neurocrit Care
Mainali S, Fontaine GV, Rajajee V, Montellano FA, Muehlschlegel S, Wartenberg KE, Alexander SA, Busl KM, Hocker SE, Hwang DY, Kim KS, Madzar D, Mahanes D, Meixensberger J, Sakowitz OW, Varelas PN, Weimar C, Westermaier T, Creutzfeldt CJ.   +18 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

To Reenvision and Redefine: Considering the Role of Lifestyle Interventions in the New Era of Second-Generation Obesity Management Medications. [PDF]

Curr Atheroscler Rep
Peary A, Vaidya N, Jakicic J, Chao AM.
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Mapping Aural Rehabilitation Needs in a Kannada-Speaking Population: A Focus Group Study with Adults with Hearing Loss, Their Significant Others and Audiologists. [PDF]

Audiol Res
Spoorthi GN, Shastri U, Kumar K, Kalaiah MK.   +3 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source