Results 41 to 50 of about 2,229,955 (197)

Benefits and harms of Risperidone and Paliperidone for treatment of patients with schizophrenia or bipolar disorder: a meta-analysis involving individual participant data and clinical study reports

BMC Medicine, 2021
Background Schizophrenia and bipolar disorder are severe mental illnesses which are highly prevalent worldwide. Risperidone and Paliperidone are treatments for either illnesses, but their efficacy compared to other antipsychotics and growing reports of ...
Alexander Hodkinson, Carl Heneghan, Kamal R. Mahtani, Evangelos Kontopantelis, Maria Panagioti   +4 more
doaj   +1 more source

Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review. [PDF]

, 2016
Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment, up to 70% of individuals with active epilepsy have the potential to
Marson, AG, Nolan, SJ, Sudell, M, Tudur Smith, C   +3 more
core   +1 more source

RETURNING INDIVIDUAL CLINICAL TRIAL DATA BACK TO PARTICIPANTS

, 2021
A white paper addressing the ethical and technical challenges of returning meaningful individual clinical trial results to trial ...
Dr Laurie Conklin, Dr Holly Peay, Gaglianone, Suzanne, Suzie-Ann Bakker, Vroom, Elizabeth, Dr Eric Hoffman, Olsen, Christina   +6 more
openaire   +1 more source

Quantifying heterogeneity in individual participant data meta-analysis with binary outcomes

Systematic Reviews, 2017
Background In meta-analyses (MA), effect estimates that are pooled together will often be heterogeneous. Determining how substantial heterogeneity is is an important aspect of MA.
Bo Chen, Andrea Benedetti
doaj   +1 more source

Self-Help Plus for refugees and asylum seekers: an individual participant data meta-analysis

BMJ Mental Health, 2023
Question Refugees and asylum seekers are at high risk of mental disorders due to various stressors before, during and after forceful displacement. The WHO Self-Help Plus (SH+) intervention was developed to manage psychological distress and a broad range ...
Eirini Karyotaki, Pim Cuijpers, Maritta Välimäki, Marianna Purgato, Kenneth Carswell, Ceren Acarturk, Teresa Au, Minna Anttila, Della Bailey, Rachel Churchill, Markus Koesters, Tella Lantta, Mariana Popa, Marit Sijbrandij, Federico Tedeschi, Ersin Uygun, Johannes Wancata, Corrado Barbui, Mark Van Ommeren, Wietse A Tol, Ross G White, Daniel Lakin, Emily Peckham, Jura Augustinavicius, Marx Ronald Leku, Sarah Al-Hashimi, Thomas Klein   +26 more
doaj   +1 more source

WOMAN-2 Pilot Study Data [PDF]

, 2019
Data and supporting material produced as part of a pilot study to test outcome questions for the WOMAN-2 trial of tranexamic acid for the prevention of postpartum haemorrhage.
Beaumont, Danielle, Brenner, Amy, Chaudhri, Rizwana, Chaudhri, Shahana, Edwards, Phil, Javaid, Kiran, Kayani, Aasia, Miller, Lori, Roberts, Ian, Shakur-still, Haleema   +9 more
core   +1 more source

Individual participant data meta-analyses should not ignore clustering

Journal of Clinical Epidemiology, 2013
Individual participant data (IPD) meta-analyses often analyze their IPD as if coming from a single study. We compare this approach with analyses that rather account for clustering of patients within studies.Comparison of effect estimates from logistic regression models in real and simulated examples.The estimated prognostic effect of age in patients ...
Abo-Zaid, Ghada, Guo, Boliang, Deeks, Jonathan J., Debray, Thomas P.A., Steyerberg, Ewout W., Moons, Karel G.M., Riley, Richard David   +6 more
openaire   +4 more sources

Challenges In Performing An Individual Participant–level Data Meta-analysis

European Urology Focus, 2023
Individual participant-data meta-analysis (IPDMA) uses data at the participant level to synthesize evidence on clinical decision-making. We discuss the differences from aggregate-data meta-analysis and the advantages and challenges of IPDMA. IPDMA provides an opportunity to study effect modifiers at the participant level and can reduce bias in ...
Henk, van der Worp, Gea A, Holtman, Marco H, Blanker   +2 more
openaire   +2 more sources

Resource implications of preparing individual participant data from a clinical trial to share with external researchers

Trials, 2017
Background Demands are increasingly being made for clinical trialists to actively share individual participant data (IPD) collected from clinical trials using responsible methods that protect the confidentiality and privacy of clinical trial participants.
Catrin Tudur Smith, Sarah Nevitt, Duncan Appelbe, Richard Appleton, Pete Dixon, Janet Harrison, Anthony Marson, Paula Williamson, Elizabeth Tremain   +8 more
doaj   +1 more source

Meta-analysis of individual participant data: rationale, conduct, and reporting [PDF]

BMJ, 2010
The use of individual participant data instead of aggregate data in meta-analyses has many potential advantages, both statistically and clinically. Richard D Riley and colleagues describe the rationale for an individual participant data meta-analysis and outline how to conduct this type of study Meta-analysis methods involve combining and analysing ...
Riley, RD, Lambert, PC, Abo-Zaid, G
openaire   +3 more sources