Results 91 to 100 of about 1,643,276 (299)
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
The Evolution of Social Norms and Individual Preferences [PDF]
Why does an altruistically inclined player behave altruistically in some contexts and egoistically or spitefully in others? This article provides an economic explanation to this question. The basic argument is centered on the idea that social norms shape
Mauricio Villena, Rodrigo Harrison
core
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
On Acting Because of a Joint Commitment
Phenomenology and Mind, 2016 I focus on the motivational role that Gilbert attributes to joint commitment. Using Bacharach’s game theoretical analysis of non-summative group agency, I point out that Gilbert’s account of social actions conceptually requires the obliteration of ...
Silvia Tossut
doaj +1 more source
Individual versus group strategy-proofness: when do they coincide? [PDF]
A social choice function is group strategy-proof on a domain if no group of agents can manipulate its final outcome to their own benefit by declaring false preferences on that domain. Group strategy-proofness is a very attractive requirement of incentive
Bernardo Moreno +2 more
core
Learner-centred Accessibility for Interoperable Web-based Educational Systems [PDF]
, 2005 This paper describes the need for an information model and specifications that support a new strategy for delivering accessible computer-based resources to learners based on their specific needs and preferences in the circumstances in which they are ...
Andy Heath +5 more
core +1 more source
Individual preferences and social justice [PDF]
Revista Brasileira de Ciências Sociais, 2000 The article examines John Harsanyi's influential account on welfarism, according to which the satisfaction of individual preferences ought to be seen as the ultimate foundation of our social welfare (or social justice) judgments. The author argues that welfarism provides a very defective morality and that we should strive to identify a non-subjective ...
openaire +3 more sources
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
Exploring factors influencing consumer preferences for automated driving vehicles
Transportation EngineeringAdopting automated driving vehicles (AVs) promises to transform transportation systems, yet understanding individual preferences is essential for effective implementation.
Pires Abdullah, Tibor Sipos
doaj +1 more source
Family Formation in France: Individual Preferences and Subsequent Outcomes [PDF]
Vienna Yearbook of Population Research, 2006 In France, as in all European countries, the birth of a first child has been increasingly delayed over time, but the reasons why individuals decide to postpone the time to become a parent still remain to be deeply investigated at the micro level. In this
Maria Rita Testa, Laurent Toulemon
doaj