Results 71 to 80 of about 1,643,276 (299)

Individual preferences modulate incentive values: Evidence from functional MRI

open access: yesBehavioral and Brain Functions, 2008
Background In most studies on human reward processing, reward intensity has been manipulated on an objective scale (e.g., varying monetary value). Everyday experience, however, teaches us that objectively equivalent rewards may differ substantially in ...
Bosch Volker   +4 more
doaj   +1 more source

Individualized Rank Aggregation using Nuclear Norm Regularization [PDF]

open access: yes, 2014
In recent years rank aggregation has received significant attention from the machine learning community. The goal of such a problem is to combine the (partially revealed) preferences over objects of a large population into a single, relatively consistent
Lu, Yu, Negahban, Sahand N.
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Individual Preferences for Giving [PDF]

open access: yes
This paper reports an experimental test of individual preferences for giving. We use graphical representations of modified Dictator Games that vary the price of giving. This generates a very rich data set well- suited to studying behavior at the level of
Daniel Markovits   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Assessing preferences for rural landscapes: An attribute based choice modelling approach

open access: yesBio-based and Applied Economics, 2020
This study adopts a choice modelling framework to disentangle individual preferences for rural landscape attributes based on the viewing of photographs of the Irish countryside.
Mary Ryan   +4 more
doaj   +1 more source

Disambiguating Nouns, Verbs, and Adjectives Using Automatically Acquired Selectional Preferences [PDF]

open access: yes, 2003
Selectional preferences have been used by word sense disambiguation (WSD) systems as one source of disambiguating information. We evaluate WSD using selectional preferences acquired for English adjective—noun, subject, and direct object grammatical ...
Briscoe Ted   +3 more
core   +4 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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