Results 41 to 50 of about 106,832 (291)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
P080 Self-management individualised learning environment in rheumatoid arthritis
Rheumatology, 2022 Abstract Background/Aims An important but insufficient aspect of care in people with inflammatory arthritis (IA) is empowering them to acquire a good understanding of their disease and build their ability to deal effectively with the practical, physical and psychological impacts of it.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Exploring the changing role of learning support teachers in the Western Cape, South Africa
Perspectives in Education, 2013 The South African education system is continuously changing and adapting to address the challenges to provide access, equal and quality education in a new democratic dispensation.
Lorna M. Dreyer
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2021 Background Despite well-established benefits of physical activity for knee osteoarthritis (OA), nine of ten people with knee OA are inactive. People with knee OA who are inactive often believe that physical activity is dangerous, fearing that it will ...
Tasha R. Stanton +17 more
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Frontiers in Psychology, 2022 Sound-producing movements in percussion performance require a high degree of fine motor control. However, there remains a relatively limited empirical understanding of how performance level abilities develop in percussion performance in general, and ...
Tristan Loria +4 more
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Enhancing individualised learning and interaction in online learning environments
, 2008 The quality of the student learning experience in an online learning course has raised many debates in educational studies. Evidence found in current literature indicates that individualised learning and interactive learning do contribute to the student learning experience in online learning courses.
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cogent EducationIt is well documented that the impact of assessments on students’ learning is profound. There have been initiatives to incorporate innovative assessments in accounting and finance education to enhance students’ learning experience in various ways ...
Ling Xiao, Teddy Foster
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