Results 151 to 160 of about 14,964 (268)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Three ethical approaches to expanding newborn screening through genomics: a critical comparative analysis. [PDF]

BMC Med Ethics
Watts G, Otlowski M, Banks R, Newson AJ.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cultural barriers influencing virtual community of practice: a scopic review. [PDF]

BMC Psychol
Manzoor S, Atiq N.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Future Orientation in Adolescents: Development and the Roles of Parenting in Different Income Countries. [PDF]

J Youth Adolesc
Basilici MC, Gorla L, Lansford JE, Alampay LP, Al-Hassan SM, Bacchini D, Bornstein MH, Chang L, Deater-Deckard K, Giunta LD, Dodge KA, Gurdal S, Junla D, Oburu P, Pastorelli C, Skinner AT, Sorbring E, Steinberg L, Uribe Tirado LM, Yotanyamaneewong S, Liu Q, Long Q.   +21 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Collaborative relationships, disciplinary and global culture, social identity and scientific status shape how scholars cite prior work. [PDF]

Commun Psychol
Xia X, Ouellet M, Patankar SP, Stallworthy IC, Brynildsen JK, Tamir DI, Bassett DS.   +6 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Perceived ageism, macro-level sociopolitical factors, and subjective well-being: a cross-national study of older adults in 43 societies. [PDF]

J Gerontol B Psychol Sci Soc Sci
Chen X, Meng F.
europepmc   +1 more source