Results 41 to 50 of about 308,507 (245)

Culture, Institutions and the Wealth of Nations [PDF]

We construct an endogenous growth model that includes a cultural variable along the dimension of individualism-collectivism. The model predicts that more individualism leads to more innovation because of the social rewards associated with innovation in ...
Gorodnichenko, Yuriy, Roland, Gerald
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A century of methodological individualism part 2: Mises and Hayek [PDF]

, 2010
2009 marks the centenary of methodological individualism (MI). The phrase was first used in English in a 1909 paper by Joseph Schumpeter in the Quarterly Journal of Economics.
Denis, A.
core  

The institutional shaping of management: in the tracks of English individualism [PDF]

, 2006
Globalisation raises important questions about the shaping of economic action by cultural factors. This article explores the formation of what is seen by some as a prime influence on the formation of British management: individualism.
Alistair Mutch, Broadie A., Brown C.G., Buchan J., Calori R., Camic C., Campbell J., Carter I., Chandler A.D., Clark J., Colley L., Duffy E., Duffy E., Faith R., French H.R., Ganter H., Gantman E., Grey C., Herman A., Hill C., Hollister C.W., Jeremy D., Jeremy D., Jones G., Lambert S., Lane C., Law B., Macfarlane A., Marshall G., Mepham M.J., Miller H., Moody M., Morgan D.A., Morris R., Mutch A., Mutch A., Neale G., Parker R., Pryor F., Ransome P., Richards E., Richards E., Richards E., Robbins K., Robbins K., Rodger N.A., Rosie G., Skinner A.S., Spring D., Strawhorn J., Todd M., Torrance J., Ure D., Wall J., Whitley R., Whittle J., Whyman S.E., Wood M.   +57 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Terrorismo individual = Individual terrorism

EUNOMÍA. Revista en Cultura de la Legalidad, 2018
Resumen: Los atentados perpetrados por actores solitarios en los últimos años han despertado el interés del legislador por la figura del terrorismo individual. No obstante, aunque este se regula en las últimas reformas penales, no se ha dispuesto una definición del mismo en términos positivos, sino que ésta únicamente se dispone en términos negativos ...
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

For an Impure, Antiauthoritarian Ethics [PDF]

, 2018
My commentary deals with the fourth chapter of Against Purity, entitled “Consuming Suffering,” where Shotwell invites us to imagine what an alternative to ethical individualism might look like in practice.
Doan, Michael D.
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source